EFF_DVB-regex-v03.py 26.3 KB
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499 500 501 502 503 504 505 506 507 508 509 510 511 512 513 514 515 516 517 518 519 520 521 522 523 524 525 526 527 528 529 530 531 532 533 534 535 536
import fileinput
#import regex as re
#from regex import finditer
# We use Python3 and we had to eliminate option overlapped from finditer method of re
# As Daniel created this Python script in Python 2.7, he used overlapped, but in
# Python 3 this option was eliminated.
import re
from re import finditer
import sys
import os
import json

if (len(sys.argv) != 8):
    sys.stderr.write("E: usage: " + sys.argv[
        0] + " <input_path> <input_file> <output_path> <output_file> <normalized_Effects> <entity_path> <entity_file>\n")
    sys.stderr.flush();
    exit(2);

# LEER ARCHIVO INPUT
# Original Daniel: text_file = open( sys.argv[1], "r" )
# Original Daniel: dato = text_file.read()
# Original Daniel: text_file.close()
filename = sys.argv[2]
input_file = open(os.path.join(sys.argv[1], filename), "r")
#print("Input file: {}".format(os.path.join(sys.argv[1], sys.argv[2])))
dato = input_file.read()
input_file.close()

# Loading normalized effects
# print('Loading normalized effects...')
with open(os.path.join(sys.argv[5])) as diccFile:
    hashNormalizedEffects = json.load(diccFile)

# USING ALREADY TAGGED ENTITIES OF THE FILE (in filter sentence step)
#<entity_path> <entity_file>
# READ DICTIONARY WITH ALREADY TAGGED ENTITIES
entity_path = sys.argv[6]
entity_file = sys.argv[7]
print('Loading dictionaries with already tagged entities...')
with open(os.path.join(entity_path, entity_file)) as entFile:
    hashDicc = json.load(entFile)
print('   Loading dictionaries with already tagged entities... Done!')
# CREATE LISTS WITH ALREADY TAGGED ENTITIES OF THE FILE
regexNumFile = re.compile(r'_([0-9]+)[.-]')
result = regexNumFile.search(filename)
numFile = ""
inumFile = 0
if result:
    inumFile = int(result.group(1))
    numFile = str(inumFile)
    print("Numfile: {}".format(numFile))
else:
    print("WARNING: numfile not found in filename")

ATEREG1 = []
PTEREG1GENE = []
PTEREG1TU = []
listEffects = []

if numFile in hashDicc:
    hashTemp = hashDicc[numFile]
    # print("hashDicc[numFile]: {}".format(hashTemp))
    for k, v in hashTemp.items():
        if v == "TF":
            # print("Verifiying TF")
            if k not in ATEREG1:
                # print(" TF {}".format(k))
                ATEREG1.append(k)
        elif v == "GENE":
            if k not in PTEREG1GENE:
                PTEREG1GENE.append(k)
        elif v == "TU":
            if k not in PTEREG1TU:
                PTEREG1TU.append(k)
        elif v == "EFFECT":
            if k not in listEffects:
                listEffects.append(k)
        else:
            print("WARNING: entity not found in dictionaries")
else:
    print("WARNING: numfile not found in dictionaries")

# QUITA EXTENSION DE NOMBRE DE ARCHIVO
# Original Daniel: split_line = sys.argv[2]
output_path = sys.argv[3]
# Original Daniel: split_line = split_line[:-4]
# Original Daniel: file_name = split_line + ".a2"
input_file_name = sys.argv[2]
# Original Daniel: open( file_name , 'w').close()
file_name_entities_complete = os.path.join(output_path, "complete-ris", input_file_name[:-4] + ".a1")
file_name_interactions_complete = os.path.join(output_path, "complete-ris", input_file_name[:-4] + ".a2")
file_name_entities_incomplete = os.path.join(output_path, "incomplete-ris", input_file_name[:-4] + ".a1")
file_name_interactions_incomplete = os.path.join(output_path, "incomplete-ris", input_file_name[:-4] + ".a2")

file_name_text_complete = os.path.join(output_path, "complete-ris", input_file_name[:-4] + ".txt")
file_name_text_incomplete = os.path.join(output_path, "incomplete-ris", input_file_name[:-4] + ".txt")

open(file_name_entities_complete, 'w').close()
open(file_name_interactions_complete, 'w').close()
# Original Daniel: open( file_name , 'w').close()
open(file_name_entities_incomplete, 'w').close()
open(file_name_interactions_incomplete, 'w').close()

# declara variables
# Original Daniel: impresion = []
impresionEntities = []
impresionInteractionsComplete = []
impresionInteractionsIncomplete = []
salida_a2 = []
salida_a2_trimmed = []
salida_a2_str = []
q2line = ()
listadeRIs = []
posiblesminimos = [[], []]
posiblesmaximos = [[], []]
listasecundaria = []
listasecundaria_trimmed = []
impresionEntities = []
impresionInteractionsComplete = []
impresionInteractionsIncomplete = []

# Effects
for i in range(len(listEffects)):
    if listEffects[i] in dato:
        for match in finditer(r'\b(' + listEffects[i] + r')\b(\s\b(of|at|for)\b)', dato):  # "of","for" o "at" a la derecha de EFF
        # Original Daniel: for match in finditer(r'\b(' + listEffects[i] + r')\b(\s\b(of|at)\b)', dato,
        # Original Daniel:                       overlapped=True):  # "of" o "at" a la derecha de EFF
            spantup = match.span(1)
            # Original Daniel: a2line = ('deverbal_effect', spantup[0], spantup[1], match.group(1))
            if match.group(1).lower() in hashNormalizedEffects:
                effect = "EFFECT." + hashNormalizedEffects[match.group(1).lower()]
            else:
                effect = "EFFECT." + "deverbal_effect"
            # Original Daniel: a2line = (effect, spantup[0], spantup[1], match.group(1))
            a2line = (effect, spantup[0], spantup[1] - 1, match.group(1))
            #print("Append effect a2line: {}".format(a2line))
            salida_a2.append(a2line)
        for match in finditer(r'\b(' + listEffects[i] + r')\b(\s\bby\b)', dato):  # "by" a la derecha de EFF
            # Original Daniel: for match in finditer(r'\b(' + listEffects[i] + r')\b(\s\bby\b)', dato,
            # Original Daniel:                       overlapped=True):  # "by" a la derecha de EFF
            spantup = match.span(1)
            # Original Daniel: a2line = ('deverbal_effect', spantup[0], spantup[1], match.group(1))
            if match.group(1).lower() in hashNormalizedEffects:
                effect = "EFFECT." + hashNormalizedEffects[match.group(1).lower()]
            else:
                effect = "EFFECT." + "deverbal_effect"
            # Original Daniel: a2line = (effect, spantup[0], spantup[1], match.group(1))
            a2line = (effect, spantup[0], spantup[1] - 1, match.group(1))
            salida_a2.append(a2line)
            #print("Append effect a2line: {}".format(a2line))
        for match in finditer(r'(is\sthe\s(\S+\s){0,1})\b(' + listEffects[i] + r')\b', dato):  # "is the" 0-1 palabras a la izquierda de EFF
            # Original Daniel: for match in finditer(r'(is\sthe\s(\S+\s){0,1})\b(' + listEffects[i] + r')\b', dato,
            # Original Daniel:                   overlapped=True):  # "is the" 0-1 palabras a la izquierda de EFF
            spantup = match.span(3)
            # Original Daniel: a2line = ('deverbal_effect', spantup[0], spantup[1], match.group(3))
            if match.group(1).lower() in hashNormalizedEffects:
                effect = "EFFECT." + hashNormalizedEffects[match.group(1).lower()]
            else:
                effect = "EFFECT." + "deverbal_effect"
            # Original Daniel: a2line = (effect, spantup[0], spantup[1], match.group(3))
            a2line = (effect, spantup[0], spantup[1] - 1, match.group(3))
            salida_a2.append(a2line)
            #print("Append effect a2line: {}".format(a2line))
#print("Efectos salida_a2: {}".format(salida_a2))

# PTEREG1GENE regulados pacientes GENE
for i in range(len(PTEREG1GENE)):
    if PTEREG1GENE[i] in dato:
        # print(PTEREG1GENE[i])
        for match in finditer(r'\b(of|at|for)\b\s+(\w\s){0,1}\b(' + PTEREG1GENE[i] + r')\b', dato):  # "of", "for" o "at" 0-1 palabras a la izq de regulado
            # Original Daniel: for match in finditer(r'\b(of|at)\b\s+(\w\s){0,1}\b(' + PTEREG1GENE[i] + r')\b', dato,
            # Original Daniel:                   overlapped=True):  # "of" o "at" 0-1 palabras a la izq de regulado
            spantup = match.span(3)
            # print("match {} spantup {}".format(match.group(3), match.span(3)))
            # Original Daniel: a2line = ('regulated', spantup[0], spantup[1], match.group(3))
            a2line = ('GENE', spantup[0], spantup[1] - 1, match.group(3))
            salida_a2.append(a2line)
            # print("Append regulados a2line: {}".format(a2line))
        for match in finditer(r'\b(' + PTEREG1GENE[i] + r')\b', dato):  # regulados sin patron
            # Original Daniel: for match in finditer(r'\b(' + PTEREG1GENE[i] + r')\b', dato, overlapped=True):  # regulados sin patron
            spantup = match.span(1)
            # print("match {} spantup {}".format(match.group(1), match.span(1)))
            # Original Daniel: a2line = ('regulated', spantup[0], spantup[1], match.group(1))
            a2line = ('GENE', spantup[0], spantup[1] - 1, match.group(1))
            listasecundaria.append(a2line)
#print("Efectos regulados gene listasecundaria: {}".format(listasecundaria))

# CMC: ADDED TO SEPARTE REGULATED GENE AND TU
# PTEREG1TU regulados pacientes TU
for i in range(len(PTEREG1TU)):
    if PTEREG1TU[i] in dato:
        # print(PTEREG1TU[i])
        for match in finditer(r'\b(of|at|for)\b\s+(\w\s){0,1}\b(' + PTEREG1TU[i] + r')\b', dato):  # "of","for" o "at" 0-1 palabras a la izq de regulado
            # Original Daniel: for match in finditer(r'\b(of|at)\b\s+(\w\s){0,1}\b(' + PTEREG1TU[i] + r')\b', dato,
            # Original Daniel:                   overlapped=True):  # "of" o "at" 0-1 palabras a la izq de regulado
            spantup = match.span(3)
            # print("match: " + match.group(3))
            # Original Daniel: a2line = ('regulated', spantup[0], spantup[1], match.group(3))
            a2line = ('TU', spantup[0], spantup[1] - 1, match.group(3))
            salida_a2.append(a2line)
            # print("Append regulados a2line: {}".format(a2line))
        for match in finditer(r'\b(' + PTEREG1TU[i] + r')\b', dato):  # regulados sin patron
        # for match in finditer(r'\b(' + PTEREG1TU[i] + r')\b', dato, overlapped=True):  # regulados sin patron
            spantup = match.span(1)
            # Original Daniel: a2line = ('regulated', spantup[0], spantup[1], match.group(1))
            a2line = ('TU', spantup[0], spantup[1] - 1, match.group(1))
            listasecundaria.append(a2line)
#print("Efectos regulados tu listasecundaria: {}".format(listasecundaria))

# ATEREG1 reguladores agentes
for i in range(len(ATEREG1)):
    if ATEREG1[i] in dato:
        # print(ATEREG1[i])
        for match in finditer(r'\bby\b\s+(\w\s){0,1}\b(' + ATEREG1[i] + r')\b', dato):  # "by" 0-1 palabras a la izq de regulado
            # Original Daniel: for match in finditer(r'\bby\b\s+(\w\s){0,1}\b(' + ATEREG1[i] + r')\b', dato,
            # Original Daniel:                   overlapped=True):  # "by" 0-1 palabras a la izq de regulado
            spantup = match.span(2)
            # print("match: " + match.group(2))
            # print("match {} spantup {}".format(match.group(2), match.span(2)))
            # Original Daniel: a2line = ('regulator', spantup[0], spantup[1], match.group(2))
            a2line = ('TF', spantup[0], spantup[1] - 1, match.group(2))
            salida_a2.append(a2line)
            #print("Append regulator a2line: {}".format(a2line))
        for match in finditer(r'\b(' + ATEREG1[i] + r')\b', dato):  # reguladores sin patron
        # for match in finditer(r'\b(' + ATEREG1[i] + r')\b', dato, overlapped=True):  # reguladores sin patron
            spantup = match.span(1)
            # print("match {} spantup {}".format(match.group(1), match.span(1)))
            # Original Daniel: a2line = ('regulator', spantup[0], spantup[1], match.group(1))
            a2line = ('TF', spantup[0], spantup[1] - 1, match.group(1))
            listasecundaria.append(a2line)
            #print("Append regulator a2line: {}".format(a2line))
#print("Reguladores agentes salida_a2: {}".format(salida_a2))
#print("Reguladores agentes listasecundaria: {}".format(listasecundaria))

# Elimina etiquetados repetidos o que estan incluidos en otros
if salida_a2:
    salida_a2.sort(key=lambda tup: tup[1])
    salida_a2_trimmed.append(salida_a2[0])
    for i in range(len(salida_a2)):
        copiar = True
        for j in range(len(salida_a2_trimmed)):
            if ((salida_a2[i][1] >= salida_a2_trimmed[j][1]) and (salida_a2[i][2] <= salida_a2_trimmed[j][2])):
                copiar = False
        if copiar:
            salida_a2_trimmed.append(salida_a2[i])
if listasecundaria:
    listasecundaria.sort(key=lambda tup: tup[1])
    listasecundaria_trimmed.append(listasecundaria[0])
    for i in range(len(listasecundaria)):
        copiar = True
        for j in range(len(listasecundaria_trimmed)):
            if ((listasecundaria[i][1] >= listasecundaria_trimmed[j][1]) and (
                listasecundaria[i][2] <= listasecundaria_trimmed[j][2])):
                copiar = False
        if copiar:
            listasecundaria_trimmed.append(listasecundaria[i])
# print("Sin repeticiones salida_a2_trimmed: {}".format(salida_a2_trimmed))
#print("Sin repeticiones listasecundaria_trimmed: {}".format(listasecundaria_trimmed))

# Asigna identificadores (TX) a entidades (eff, regulador, regulado)
lastID = 0
for i in range(len(salida_a2_trimmed)):
    # if sys.argv[2].find('355') > -1:
    #    print("i : {}".format(i))
    salida_a2_trimmed[i] = list(salida_a2_trimmed[i])
    ID = "T" + str(i + 1)
    salida_a2_trimmed[i].insert(0, ID)
    lastID = i + 1
    # if sys.argv[2].find('355') > -1:
    #    print("lastID : {}".format(lastID))

for i in range(len(listasecundaria_trimmed)):
    # if sys.argv[2].find('355') > -1:
    #    print("i : {}".format(i))
    #    print("lastID : {}".format(lastID))
    listasecundaria_trimmed[i] = list(listasecundaria_trimmed[i])
    ID = "T" + str(i + 1 + lastID)
    listasecundaria_trimmed[i].insert(0, ID)

# print("Con identificadores salida_a2_trimmed: {}".format(salida_a2_trimmed))
#print("Con identificadores listasecundaria_trimmed: {}".format(listasecundaria_trimmed))

#print("salida_a2_trimmed")  #########################
#print(salida_a2_trimmed)  #########################
#print("listasecundaria_trimmed")
#print(listasecundaria_trimmed)

# Arma Interacciones Regulatorias
i = 0
while i < int(len(salida_a2_trimmed)):
    if "EFFECT" in salida_a2_trimmed[i][1]:
        # BUSCA REGULADO A LA DERECHA
        nuevaRI = [salida_a2_trimmed[i][0], "", ""]  # efecto, tema, causa
        ref = ""
        posiblesminimos = [[], []]
        j = 0
        while j < int(len(salida_a2_trimmed)):
            # Original Daniel: if ("regulated" in salida_a2_trimmed[j][1]) and (salida_a2_trimmed[i][3] < salida_a2_trimmed[j][2]):
            if ("GENE" in salida_a2_trimmed[j][1] or "TU" in salida_a2_trimmed[j][1]) and (salida_a2_trimmed[i][3] < salida_a2_trimmed[j][2]):
                posiblesminimos[0].append(salida_a2_trimmed[j][2])
                posiblesminimos[1].append(salida_a2_trimmed[j][0])
            j = j + 1
        if posiblesminimos[0]:
            refpointer = posiblesminimos[0].index(min(posiblesminimos[0]))
            ref = posiblesminimos[1][refpointer]
        # si no encuentra, BUSCA REGULADO A LA IZQUIERDA
        if not ref:
            posiblesmaximos = [[], []]
            j = 0
            while j < int(len(salida_a2_trimmed)):
                # Original Daniel: if ("regulated" in salida_a2_trimmed[j][1]) and (salida_a2_trimmed[i][2] > salida_a2_trimmed[j][3]):
                if ("GENE" in salida_a2_trimmed[j][1] or "TU" in salida_a2_trimmed[j][1]) and (salida_a2_trimmed[i][2] > salida_a2_trimmed[j][3]):
                    posiblesmaximos[0].append(salida_a2_trimmed[j][3])
                    posiblesmaximos[1].append(salida_a2_trimmed[j][0])
                j = j + 1
            if posiblesmaximos[0]:
                refpointer = posiblesmaximos[0].index(max(posiblesmaximos[0]))
                ref = posiblesmaximos[1][refpointer]
        nuevaRI[1] = ref
        # BUSCA REGULADOR A LA DERECHA
        ref = ""
        posiblesminimos = [[], []]
        j = 0
        while j < int(len(salida_a2_trimmed)):
            # Original Daniel: if ("regulator" in salida_a2_trimmed[j][1]) and (salida_a2_trimmed[i][3] < salida_a2_trimmed[j][2]):
            if ("TF" in salida_a2_trimmed[j][1]) and (salida_a2_trimmed[i][3] < salida_a2_trimmed[j][2]):
                posiblesminimos[0].append(salida_a2_trimmed[j][2])
                posiblesminimos[1].append(salida_a2_trimmed[j][0])
            j = j + 1
        if posiblesminimos[0]:
            refpointer = posiblesminimos[0].index(min(posiblesminimos[0]))
            ref = posiblesminimos[1][refpointer]
        # si no encuentra, BUSCA REGULADOR A LA IZQUIERDA
        if not ref:
            posiblesmaximos = [[], []]
            j = 0
            while j < int(len(salida_a2_trimmed)):
                # Original Daniel: if ("regulator" in salida_a2_trimmed[j][1]) and (salida_a2_trimmed[i][2] > salida_a2_trimmed[j][3]):
                if ("TF" in salida_a2_trimmed[j][1]) and (salida_a2_trimmed[i][2] > salida_a2_trimmed[j][3]):
                    posiblesmaximos[0].append(salida_a2_trimmed[j][3])
                    posiblesmaximos[1].append(salida_a2_trimmed[j][0])
                j = j + 1
            if posiblesmaximos[0]:
                refpointer = posiblesmaximos[0].index(max(posiblesmaximos[0]))
                ref = posiblesmaximos[1][refpointer]
        nuevaRI[2] = ref
        listadeRIs.append(nuevaRI)
    i = i + 1

# SEGUNDA FASE DE BUSQUEDA DE REGULADORES Y REGULADOS
i = 0
while i < int(len(listadeRIs)):
    if not listadeRIs[i][1]:  # no regulado
        ref = ""
        posiblesminimos = [[], []]
        # BUSCA REGULADO A LA DERECHA
        j = 0
        while j < int(len(listasecundaria_trimmed)):
            for k in range(len(salida_a2_trimmed)):
                if listadeRIs[i][0] == salida_a2_trimmed[k][0]:
                    ind = k
            # Original Daniel: if ("regulated" in listasecundaria_trimmed[j][1]) and (salida_a2_trimmed[ind][3] < listasecundaria_trimmed[j][2]):
            if ("GENE" in listasecundaria_trimmed[j][1] or "TU" in listasecundaria_trimmed[j][1]) and (salida_a2_trimmed[ind][3] < listasecundaria_trimmed[j][2]):
                posiblesminimos[0].append((listasecundaria_trimmed[j][2] - salida_a2_trimmed[ind][3]))
                posiblesminimos[1].append(listasecundaria_trimmed[j][0])
            j = j + 1
        # BUSCA REGULADO A LA IZQUIERDA
        j = 0
        while j < int(len(listasecundaria_trimmed)):
            for k in range(len(salida_a2_trimmed)):
                if listadeRIs[i][0] == salida_a2_trimmed[k][0]:
                    ind = k
            # Original Daniel: if ("regulated" in listasecundaria_trimmed[j][1]) and (salida_a2_trimmed[ind][2] > listasecundaria_trimmed[j][3]):
            if ("GENE" in listasecundaria_trimmed[j][1] or "TU" in listasecundaria_trimmed[j][1]) and (salida_a2_trimmed[ind][2] > listasecundaria_trimmed[j][3]):
                posiblesminimos[0].append((salida_a2_trimmed[ind][2] - listasecundaria_trimmed[j][3]))
                posiblesminimos[1].append(listasecundaria_trimmed[j][0])
            j = j + 1
        # ELIGE EL REGULADO MAS CERCANO
        if posiblesminimos[0]:
            refpointer = posiblesminimos[0].index(min(posiblesminimos[0]))
            ref = posiblesminimos[1][refpointer]
        # print(ref)
        listadeRIs[i][1] = ref
    if not listadeRIs[i][2]:  # no regulador
        ref = ""
        posiblesminimos = [[], []]
        # BUSCA REGULADO A LA DERECHA
        j = 0
        while j < int(len(listasecundaria_trimmed)):
            for k in range(len(salida_a2_trimmed)):
                if listadeRIs[i][0] == salida_a2_trimmed[k][0]:
                    ind = k
            # Original Daniel: if ("regulator" in listasecundaria_trimmed[j][1]) and (salida_a2_trimmed[ind][3] < listasecundaria_trimmed[j][2]):
            if ("TF" in listasecundaria_trimmed[j][1]) and (salida_a2_trimmed[ind][3] < listasecundaria_trimmed[j][2]):
                posiblesminimos[0].append((listasecundaria_trimmed[j][2] - salida_a2_trimmed[ind][3]))
                posiblesminimos[1].append(listasecundaria_trimmed[j][0])
            j = j + 1
        # BUSCA REGULADO A LA IZQUIERDA
        j = 0
        while j < int(len(listasecundaria_trimmed)):
            for k in range(len(salida_a2_trimmed)):
                if listadeRIs[i][0] == salida_a2_trimmed[k][0]:
                    ind = k
            # Original Daniel: if ("regulator" in listasecundaria_trimmed[j][1]) and (salida_a2_trimmed[ind][2] > listasecundaria_trimmed[j][3]):
            if ("TF" in listasecundaria_trimmed[j][1]) and (salida_a2_trimmed[ind][2] > listasecundaria_trimmed[j][3]):
                posiblesminimos[0].append((salida_a2_trimmed[ind][2] - listasecundaria_trimmed[j][3]))
                posiblesminimos[1].append(listasecundaria_trimmed[j][0])
            j = j + 1
        # ELIGE EL REGULADO MAS CERCANO
        if posiblesminimos[0]:
            refpointer = posiblesminimos[0].index(min(posiblesminimos[0]))
            ref = posiblesminimos[1][refpointer]
        # print(ref)
        listadeRIs[i][2] = ref
    i = i + 1
#print("ListadeRIs: {}".format(listadeRIs))

# Elige reguladores y regulados de la listasecundaria para ser impresos
setmem = []
k = 0
while k < int(len(listadeRIs)):
    j = 0
    copysec = False
    #while j < int(len(listasecundaria_trimmed)):
    while j < len(listasecundaria_trimmed):
        # print("listasecundaria_trimmed {} and listadeRIs {}".format(listasecundaria_trimmed, listadeRIs))
        # Original Daniel: if listasecundaria_trimmed[j][0] == listadeRIs[k][1]:
        if listasecundaria_trimmed[j][0] == listadeRIs[k][2]:
            # print("listasecundaria_trimmed[j][0] {} == listadeRIs[k][2] {}".format(listasecundaria_trimmed[j][0],
            #                                                                        listadeRIs[k][2]))
            copysec = True
            # print("j: {}".format(j))
            indj = j
        j = j + 1
    if copysec:
        setmem.append(listasecundaria_trimmed[indj])
        # print("setmen: {}".format(setmem))

    #### CMC: AGREGO ESTE CODIGO PARA BUSCAR REGULADOS YA QUE EL CODIGO ANTERIOR BUSCA REGULADORES
    j = 0
    copysec = False
    #while j < int(len(listasecundaria_trimmed)):
    while j < len(listasecundaria_trimmed):
        # print("listasecundaria_trimmed {} and listadeRIs {}".format(listasecundaria_trimmed, listadeRIs))
        # Original Daniel: if listasecundaria_trimmed[j][0] == listadeRIs[k][1]:
        if listasecundaria_trimmed[j][0] == listadeRIs[k][1]:
            # print("listasecundaria_trimmed[j][0] {} == listadeRIs[k][1] {}".format(listasecundaria_trimmed[j][0],
            #                                                                       listadeRIs[k][1]))
            copysec = True
            # print("j: {}".format(j))
            indj = j
        j = j + 1
    if copysec:
        setmem.append(listasecundaria_trimmed[indj])
        # print("setmen: {}".format(setmem))

    k = k + 1
setmem = sorted(setmem)
# print("setmen: {}".format(setmem))
dedup = [setmem[i] for i in range(len(setmem)) if i == 0 or setmem[i] != setmem[i - 1]]
# print("dedup: {}".format(dedup))
salida_a2_trimmed.extend(dedup)
#print("salida_a2_trimmed after listasecundaria_trimmed: {}".format(salida_a2_trimmed))

# Asigna identificadores (EX) a eventos (RIs)
for i in range(len(listadeRIs)):
    # Original Daniel: ID = "E" + str(i+1)
    ID = "R" + str(i + 1)
    listadeRIs[i].insert(0, ID)
#print("Con identificadores ListadeRIs: {}".format(listadeRIs))

# CREA LISTADO DE EVENTOS (EX) Y ENTIDADES (TX) EN FORMATO DE IMPESIÓN
for i in range(len(salida_a2_trimmed)):
    linea = str(salida_a2_trimmed[i][0]) + '	' + str(salida_a2_trimmed[i][1]) + ' ' + str(
        salida_a2_trimmed[i][2]) + ' ' + str(salida_a2_trimmed[i][3]) + '	' + str(salida_a2_trimmed[i][4])
    # Original Daniel: impresion.append(linea)
    impresionEntities.append(linea)

for i in range(len(listadeRIs)):
    if listadeRIs[i][2] and listadeRIs[i][3]:
        # Original Daniel: linea = str(listadeRIs[i][0]) + '	' + "deverbal_effect:" + str(listadeRIs[i][1]) + ' ' + 'Theme:' + str(listadeRIs[i][2]) + ' ' + 'Cause:' + str(listadeRIs[i][3])
        linea = str(listadeRIs[i][0]) + '	' + "Interaction." + str(listadeRIs[i][1]) + ' ' + 'Target:' + str(
            listadeRIs[i][2]) + ' ' + 'Agent:' + str(listadeRIs[i][3])
        # Original Daniel: elif listadeRIs[i][2]:
        # Original Daniel: linea = str(listadeRIs[i][0]) + '	' + "deverbal_effect:" + str(listadeRIs[i][1]) + ' ' + 'Theme:' + str(listadeRIs[i][2])
        # Original Daniel: elif listadeRIs[i][3]:
        # Original Daniel: linea = str(listadeRIs[i][0]) + '	' + "deverbal_effect:" + str(listadeRIs[i][1]) + ' ' + 'Cause:' + str(listadeRIs[i][3])
        # Original Daniel: else:
        # Original Daniel: linea = str(listadeRIs[i][0]) + '	' + "deverbal_effect:" + str(listadeRIs[i][1])
        # Original Daniel: impresion.append(linea)
        impresionInteractionsComplete.append(linea)
        #print("Interaction complete: {}".format(linea))
        linea = str(listadeRIs[i][0]) + '	' + "Interaction.regulator" + ' ' + 'Target:' + str(
            listadeRIs[i][2]) + ' ' + 'Agent:' + str(listadeRIs[i][3])
        impresionInteractionsIncomplete.append(linea)

#print("Entities: {}".format(impresionEntities))

# Escribir entidades interacciones completas en a1
for line in impresionEntities:
    # Original Daniel: save_file = open( file_name, "a" )
    save_file = open(file_name_entities_complete, "a")
    save_file.write(line)
    save_file.write("\n")
    save_file.close()

# Escribir entidades interacciones incompletas en a1
for line in impresionEntities:
    # Original Daniel: save_file = open( file_name, "a" )
    save_file = open(file_name_entities_incomplete, "a")
    save_file.write(line)
    save_file.write("\n")
    save_file.close()

# Escribir interacciones completas (regulator, effect, regulated)
# print("InteractionsComplete: {}".format(impresionInteractionsComplete))
for line in impresionInteractionsComplete:
    # Original Daniel: save_file = open( file_name, "a" )
    save_file = open(file_name_interactions_complete, "a")
    save_file.write(line)
    save_file.write("\n")
    save_file.close()

# Escribir interacciones incompletas (regulator, "regulator", regulated)
# print("InteractionsIncomplete: {}".format(impresionInteractionsIncomplete))
for line in impresionInteractionsIncomplete:
    # Original Daniel: save_file = open( file_name, "a" )
    save_file = open(file_name_interactions_incomplete, "a")
    save_file.write(line)
    save_file.write("\n")
    save_file.close()

with open(file_name_text_complete, mode="w") as txtFile:
    txtFile.write(dato)
with open(file_name_text_incomplete, mode="w") as txtFile:
    txtFile.write(dato)