Recent advances in molecular targets and treatment of idiopathic pulmonary fibrosis: focus on TGFbeta signaling and the myofibroblast
Tissue inhibitor of metalloproteinase-3 is up-regulated by transforming growth factor-beta1 in vitro and expressed in fibroblastic foci in vivo in idiopathic pulmonary fibrosis
Defective histone acetylation is responsible for the diminished expression of cyclooxygenase 2 in idiopathic pulmonary fibrosis
EZH2 enhances the differentiation of fibroblasts into myofibroblasts in idiopathic pulmonary fibrosis
y-Herpes virus-68, but not Pseudomonas aeruginosa or influenza A (H1N1), exacerbates established murine lung fibrosis
Microarray identifies ADAM family members as key responders to TGF-beta1 in alveolar epithelial cells
Anti-pulmonary fibrotic activity of salvianolic acid B was screened by a novel method based on the cyto-biophysical properties
Targeting genes for treatment in idiopathic pulmonary fibrosis: challenges and opportunities, promises and pitfalls
Th1/Th2 cytokine gene polymorphisms in patients with idiopathic pulmonary fibrosis
VCAM-1 is a TGF-b1 inducible gene upregulated in idiopathic pulmonary fibrosis
Integrated analyses identify the involvement of microRNA-26a in epithelial-mesenchymal transition during idiopathic pulmonary fibrosis
Upregulation of alveolar levels of activin B, but not activin A, in lungs of west highland white terriers with idiopathic pulmonary fibrosis and diffuse alveolar damage
Roles for insulin-like growth factor I and transforming growth factor-beta in fibrotic lung disease
Combined inhibition of TGFb and PDGF signaling attenuates radiation-induced pulmonary fibrosis
Glucagon like peptide-1 attenuates bleomycin-induced pulmonary fibrosis, involving the inactivation of NF-kB in mice
Carbon monoxide-bound hemoglobin-vesicles for the treatment of bleomycin-induced pulmonary fibrosis
Protease activated receptor-1 regulates macrophage-mediated cellular senescence: a risk for idiopathic pulmonary fibrosis
Control of virus reactivation arrests pulmonary herpesvirus-induced fibrosis in IFN-gamma receptor-deficient mice
Regulation of TGF-b storage and activation in the human idiopathic pulmonary fibrosis lung
Interleukin-17 induces human alveolar epithelial to mesenchymal cell transition via the TGF-b1 mediated Smad2/3 and ERK1/2 activation
Prognostic factors for idiopathic pulmonary fibrosis: clinical, physiologic, pathologic, and molecular aspects
Progressive transforming growth factor beta1-induced lung fibrosis is blocked by an orally active ALK5 kinase inhibitor
Toll-like receptor 4 activation attenuates profibrotic response in control lung fibroblasts but not in fibroblasts from patients with IPF
Free radical generation induces epithelial-to-mesenchymal transition in lung epithelium via a TGF-b1-dependent mechanism
Methylation-mediated BMPER expression in fibroblast activation in vitro and lung fibrosis in mice in vivo
Upregulation of activin-B and follistatin in pulmonary fibrosis - a translational study using human biopsies and a specific inhibitor in mouse fibrosis models
Resveratrol inhibits transforming growth factor-b-induced proliferation and differentiation of ex vivo human lung fibroblasts into myofibroblasts through ERK/Akt inhibition and PTEN restoration
Effects of doxycycline on production of growth factors and matrix metalloproteinases in pulmonary fibrosis
MS80, a novel sulfated oligosaccharide, inhibits pulmonary fibrosis by targeting TGF-beta1 both in vitro and in vivo
Association of HLA and cytokine gene polymorphisms with idiopathic pulmonary fibrosis
Oxidant-antioxidant imbalance as a potential contributor to the progression of human pulmonary fibrosis
A translational preclinical model of interstitial pulmonary fibrosis and pulmonary hypertension: mechanistic pathways driving disease pathophysiology
Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis
Pirfenidone for the treatment of idiopathic pulmonary fibrosis
Interactions between b-catenin and transforming growth factor-b signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP)
Uncoupling of the profibrotic and hemostatic effects of thrombin in lung fibrosis
Studies of hepatocyte growth factor in bronchoalveolar lavage fluid in chronic interstitial lung diseases
Syndecan-2 exerts antifibrotic effects by promoting caveolin-1-mediated transforming growth factor-b receptor I internalization and inhibiting transforming growth factor-b1 signaling
Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-b signaling
Simvastatin attenuates TGF-b1-induced epithelial-mesenchymal transition in human alveolar epithelial cells
Expression of 150-kDa oxygen-regulated protein (ORP150) stimulates bleomycin-induced pulmonary fibrosis and dysfunction in mice
Kinase inhibitors fail to induce mesenchymal-epithelial transition in fibroblasts from fibrotic lung tissue
The small heat-shock protein aB-crystallin is essential for the nuclear localization of Smad4: impact on pulmonary fibrosis
Blockade of the Wnt/b-catenin pathway attenuates bleomycin-induced pulmonary fibrosis
Epithelial stem cell exhaustion in the pathogenesis of idiopathic pulmonary fibrosis
CUX1/Wnt signaling regulates epithelial mesenchymal transition in EBV infected epithelial cells
Mode of action of nintedanib in the treatment of idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis: an altered fibroblast proliferation linked to cancer biology
Lower expression of platelet derived growth factor is associated with better overall survival rate of patients with idiopathic nonspecific interstitial pneumonia
Elevated expression of NEU1 sialidase in idiopathic pulmonary fibrosis provokes pulmonary collagen deposition, lymphocytosis, and fibrosis
TGF-beta 1, but not TGF-beta 2 or TGF-beta 3, is differentially present in epithelial cells of advanced pulmonary fibrosis: an immunohistochemical study
Cthrc1 lowers pulmonary collagen associated with bleomycin-induced fibrosis and protects lung function
Pigment epithelium-derived factor in idiopathic pulmonary fibrosis: a role in aberrant angiogenesis
Cytoskeletal protein modulation in pulmonary alveolar myofibroblasts during idiopathic pulmonary fibrosis
Increased expression of 5-hydroxytryptamine2A/B receptors in idiopathic pulmonary fibrosis: a rationale for therapeutic intervention
Signaling pathways and their miRNA regulators involved in the etiopathology of idiopathic pulmonary fibrosis (IPF) and hypersensitivity pneumonitis (HP)
Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis
TGF-b1 induces tissue factor expression in human lung fibroblasts in a PI3K/JNK/Akt-dependent and AP-1-dependent manner
Inhibitory effects of amines from Citrus reticulata on bleomycin-induced pulmonary fibrosis in rats
Focal adhesion kinase signaling determines the fate of lung epithelial cells in response to TGF-b
Beyond TGFb - Novel ways to target airway and parenchymal fibrosis
Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis
The profibrotic cytokine transforming growth factor-b1 increases endothelial progenitor cell angiogenic properties
Tannic acid attenuates TGF-b1-induced epithelial-to-mesenchymal transition by effectively intervening TGF-b signaling in lung epithelial cells
Differential expression of alpha E beta 7 integrins on bronchoalveolar lavage T lymphocyte subsets: regulation by alpha 4 beta 1-integrin crosslinking and TGF-beta
Elevated sL1-CAM levels in BALF and serum of IPF patients
The potential application of strategic released apigenin from polymeric carrier in pulmonary fibrosis
Immunomodulation by mesenchymal stem cells in treating human autoimmune disease-associated lung fibrosis
Epithelial-to-mesenchymal transition and its role in EGFR-mutant lung adenocarcinoma and idiopathic pulmonary fibrosis
Effects of thymosin b4 and its N-terminal fragment Ac-SDKP on TGF-b-treated human lung fibroblasts and in the mouse model of bleomycin-induced lung fibrosis
Epithelial contribution to the pro-fibrotic stiff microenvironment and myofibroblast population in lung fibrosis
The matricellular protein CCN1 enhances TGF-b1/SMAD3-dependent profibrotic signaling in fibroblasts and contributes to fibrogenic responses to lung injury
MicroRNA-326 regulates profibrotic functions of transforming growth factor-b in pulmonary fibrosis
Significance of elevated procollagen-III-peptide and transforming growth factor-beta levels of bronchoalveolar lavage fluids from idiopathic pulmonary fibrosis patients
The latent form of TGFbeta(1) is induced by TNFalpha through an ERK specific pathway and is activated by asbestos-derived reactive oxygen species in vitro and in vivo
Protective role of gambogic acid in experimental pulmonary fibrosis in vitro and in vivo
An ex vivo model to induce early fibrosis-like changes in human precision-cut lung slices
Differential effects of human neutrophil peptide-1 on growth factor and interleukin-8 production by human lung fibroblasts and epithelial cells
Human placental mesenchymal stem cells of fetal origins-alleviated inflammation and fibrosis by attenuating MyD88 signaling in bleomycin-induced pulmonary fibrosis mice
Fibroblasts from idiopathic pulmonary fibrosis and normal lungs differ in growth rate, apoptosis, and tissue inhibitor of metalloproteinases expression
Phosphatase and tensin homolog deleted on chromosome 10 contributes to phenotype transformation of fibroblasts in idiopathic pulmonary fibrosis via multiple pathways
Release of biologically active TGF-beta1 by alveolar epithelial cells results in pulmonary fibrosis
Overproduction of collagen and diminished SOCS1 expression are causally linked in fibroblasts from idiopathic pulmonary fibrosis
Thalidomide reduces IL-18, IL-8 and TNF-alpha release from alveolar macrophages in interstitial lung disease
Pathogenesis pathways of idiopathic pulmonary fibrosis in bleomycin-induced lung injury model in mice
VEGF ameliorates pulmonary hypertension through inhibition of endothelial apoptosis in experimental lung fibrosis in rats
Genomewide RNA expression profiling in lung identifies distinct signatures in idiopathic pulmonary arterial hypertension and secondary pulmonary hypertension
Transforming growth factor-b1 downregulates vascular endothelial growth factor-D expression in human lung fibroblasts via the Jun NH2-terminal kinase signaling pathway
Corilagin attenuates aerosol bleomycin-induced experimental lung injury
Bleomycin induces molecular changes directly relevant to idiopathic pulmonary fibrosis: a model for "active" disease
Long-acting human serum albumin-thioredoxin fusion protein suppresses bleomycin-induced pulmonary fibrosis progression
Angiotensin-TGF-beta 1 crosstalk in human idiopathic pulmonary fibrosis: autocrine mechanisms in myofibroblasts and macrophages
miR-199a-5p Is upregulated during fibrogenic response to tissue injury and mediates TGFbeta-induced lung fibroblast activation by targeting caveolin-1
Increased expression of protease nexin-1 in fibroblasts during idiopathic pulmonary fibrosis regulates thrombin activity and fibronectin expression
Plasma CCN2 (connective tissue growth factor; CTGF) is a potential biomarker in idiopathic pulmonary fibrosis (IPF)
Cysteine-rich protein 1 is regulated by transforming growth factor-b1 and expressed in lung fibrosis
Microencapsulation of lefty-secreting engineered cells for pulmonary fibrosis therapy in mice
Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-b-induced senescence of human bronchial epithelial cells
Pleural mesothelial cell transformation into myofibroblasts and haptotactic migration in response to TGF-beta1 in vitro
p63 - Key molecule in the early phase of epithelial abnormality in idiopathic pulmonary fibrosis
Increased interleukin-1 receptor antagonist in idiopathic pulmonary fibrosis
Molecular pathogenesis of interstitial pneumonitis with TNF-alpha transgenic mice
Wilms' tumor 1 (Wt1) regulates pleural mesothelial cell plasticity and transition into myofibroblasts in idiopathic pulmonary fibrosis
Epithelium-specific deletion of TGF-b receptor type II protects mice from bleomycin-induced pulmonary fibrosis
Bleomycin in the setting of lung fibrosis induction: From biological mechanisms to counteractions
Assessment of the effect of potential antifibrotic compounds on total and aVb6 integrin-mediated TGF-b activation
The anti-fibrotic effect of inhibition of TGFb-ALK5 signalling in experimental pulmonary fibrosis in mice is attenuated in the presence of concurrent y-herpesvirus infection
Plasminogen activator inhibitor 1, fibroblast apoptosis resistance, and aging-related susceptibility to lung fibrosis
Antifibrotic properties of receptor for advanced glycation end products in idiopathic pulmonary fibrosis
Genetic polymorphism in matrix metalloproteinase-9 and transforming growth factor-b1 and susceptibility to combined pulmonary fibrosis and emphysema in  a Chinese population
Berberine attenuates bleomycin induced pulmonary toxicity and fibrosis via suppressing NF-kB dependant TGF-b activation: a biphasic experimental study
Transforming growth factor-b inhibits IQ motif containing guanosine triphosphatase activating protein  1 expression in lung fibroblasts via the nuclear factor-kB signaling pathway
Role of CD248 as a potential severity marker in idiopathic pulmonary fibrosis
Immunoglobulin A in serum: an old acquaintance as a new prognostic biomarker in idiopathic pulmonary fibrosis
Defect of hepatocyte growth factor secretion by fibroblasts in idiopathic pulmonary fibrosis
Possible involvement of pirfenidone metabolites in the antifibrotic action of a therapy for idiopathic pulmonary fibrosis
Effect of pirfenidone on proliferation, TGF-b-induced myofibroblast differentiation and fibrogenic activity of primary human lung fibroblasts
Olodaterol shows anti-fibrotic efficacy in in vitro and in vivo models of pulmonary fibrosis
[Quantifying plasma levels of transforming growth factor beta1 in idiopathic pulmonary fibrosis]
BAX inhibitor-1-associated V-ATPase glycosylation enhances collagen degradation in pulmonary fibrosis
Idiopathic pulmonary fibrosis: pathobiology of novel approaches to treatment
Novel pharmacological approaches to manage interstitial lung fibrosis in the twenty-first century
De-ubiquitinating enzyme, USP11, promotes transforming growth factor b-1 signaling through stabilization of transforming growth factor b receptor II
SPARC suppresses apoptosis of idiopathic pulmonary fibrosis fibroblasts through constitutive activation of beta-catenin
Aortic carboxypeptidase-like protein (ACLP) enhances lung myofibroblast differentiation through transforming growth factor b receptor-dependent and -independent pathways
IL-4 polymorphisms, HRCT score and lung tissue markers in idiopathic pulmonary fibrosis
TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT)
NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury
TGF-beta 1 as an enhancer of Fas-mediated apoptosis of lung epithelial cells
MicroRNA-29c regulates apoptosis sensitivity via modulation of the cell-surface death receptor, Fas, in lung fibroblasts
Insulin-like growth factor binding proteins 3 and 5 are overexpressed in idiopathic pulmonary fibrosis and contribute to extracellular matrix deposition
Bile acids induce activation of alveolar epithelial cells and lung fibroblasts through farnesoid X receptor-dependent and independent pathways
Fibroblastic foci, covered with alveolar epithelia exhibiting epithelial-mesenchymal transition, destroy alveolar septa by disrupting blood flow in idiopathic pulmonary fibrosis
Connective tissue growth factor expression and induction by transforming growth factor-beta is abrogated by simvastatin via a Rho signaling mechanism
Regulation of human lung fibroblast C1q-receptors by transforming growth factor-beta and tumor necrosis factor-alpha
Sorafenib ameliorates bleomycin-induced pulmonary fibrosis: potential roles in the inhibition of epithelial-mesenchymal transition and fibroblast activation
Microarray profiling reveals suppressed interferon stimulated gene program in fibroblasts from scleroderma-associated interstitial lung disease
Effects of antifibrotic agents on TGF-beta1, CTGF and IFN-gamma expression in patients with idiopathic pulmonary fibrosis
NOX4/NADPH oxidase expression is increased in pulmonary fibroblasts from patients with idiopathic pulmonary fibrosis and mediates TGFbeta1-induced fibroblast differentiation into myofibroblasts
[The expressions and meanings of BMP-7 and TGF-b in idiopathic pulmonary fibrosis and idiopathic nonspecific interstitial pneumonia]
Increased deposition of chondroitin/dermatan sulfate glycosaminoglycan and upregulation of b1,3-glucuronosyltransferase I in pulmonary fibrosis
Identification and validation of differentially expressed transcripts by RNA-sequencing of formalin-fixed, paraffin-embedded (FFPE) lung tissue from patients with Idiopathic Pulmonary Fibrosis
Increased TGF-beta1 in the lungs of asbestos-exposed rats and mice: reduced expression in TNF-alpha receptor knockout mice
Discovery and validation of extracellular/circulating microRNAs during idiopathic pulmonary fibrosis disease progression
Idiopathic pulmonary fibrosis in relation to gene polymorphisms of transforming growth factor-b1 and plasminogen activator inhibitor 1
Comparative study of transforming growth factor-b signalling and regulatory molecules in human and canine idiopathic pulmonary fibrosis
TGF-b1 T869C polymorphism may affect susceptibility to idiopathic pulmonary fibrosis and disease severity
Inhibition of PI3K prevents the proliferation and differentiation of human lung fibroblasts into myofibroblasts: the role of class I P110 isoforms
Medical treatment for pulmonary fibrosis: current trends, concepts, and prospects
Contribution of the anaphylatoxin receptors, C3aR and C5aR, to the pathogenesis of pulmonary fibrosis
Comparison between conventional and "clinical" assessment of experimental lung fibrosis
Intratracheal bleomycin causes airway remodeling and airflow obstruction in mice
Role of endoplasmic reticulum stress in age-related susceptibility to lung fibrosis
Transforming growth factor b1 (TGFb1)-induced CD44V6-NOX4 signaling in pathogenesis of idiopathic pulmonary fibrosis
Increased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in chronic fibrosing interstitial pneumonia
Pirfenidone inhibits TGF-b1-induced over-expression of collagen type I and heat shock protein 47 in A549 cells
BAL cytokine profile in different interstitial lung diseases: a focus on systemic sclerosis
Anti-fibrotic effects of nintedanib in lung fibroblasts derived from patients with idiopathic pulmonary fibrosis
Effect of an immunotoxin to folate receptor beta on bleomycin-induced experimental pulmonary fibrosis
Modulation of CD11c+ lung dendritic cells in respect to TGF-b in experimental pulmonary fibrosis
Microsatellite instability in transforming growth factor-beta 1 type II receptor gene in alveolar lining epithelial cells of idiopathic pulmonary fibrosis
Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis
Expression of suppressor of cytokine signaling 1 in the peripheral blood of patients with idiopathic pulmonary fibrosis
Prostaglandin F(2alpha) receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-beta
Sphingosine-1-phosphate lyase is an endogenous suppressor of pulmonary fibrosis: role of S1P signalling and autophagy
Roles of p38 MAPK and JNK in TGF-b1-induced human alveolar epithelial to mesenchymal transition
The role of microRNA-155/liver X receptor pathway in experimental and idiopathic pulmonary fibrosis
Sphingosine-1-phosphate is increased in patients with idiopathic pulmonary fibrosis and mediates epithelial to mesenchymal transition
Nitric oxide attenuates epithelial-mesenchymal transition in alveolar epithelial cells
Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung fibroblasts
Evaluation of permeability alteration and epithelial-mesenchymal transition induced by transforming growth factor-b1 in A549, NCI-H441, and Calu-3 cells: Development of an in vitro model of respiratory epithelial cells in idiopathic pulmonary fibrosis
Hydrogen peroxide is a diffusible paracrine signal for the induction of epithelial cell death by activated myofibroblasts
TGF-b1 stimulates HDAC4 nucleus-to-cytoplasm translocation and NADPH oxidase 4-derived reactive oxygen species in normal human lung fibroblasts
Effects of a leukotriene B4 receptor antagonist on bleomycin-induced pulmonary fibrosis
Raised serum levels of IGFBP-1 and IGFBP-2 in idiopathic pulmonary fibrosis
Inhibition of NF-kappaB signaling reduces virus load and gammaherpesvirus-induced pulmonary fibrosis
Triptolide suppresses paraquat induced idiopathic pulmonary fibrosis by inhibiting TGFB1-dependent epithelial mesenchymal transition
N-acetylcysteine downregulation of lysyl oxidase activity alleviating bleomycin-induced pulmonary fibrosis in rats
Cytokine gene polymorphisms and BALF cytokine levels in interstitial lung diseases
[The morphology and molecular bases of damage to the stem cell niche of respiratory acini in idiopathic interstitial pneumonias]
Lactic acid is elevated in idiopathic pulmonary fibrosis and induces myofibroblast differentiation via pH-dependent activation of transforming growth factor-b
Differential mRNA expression of insulin-like growth factor-1 splice variants in patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis
The hedgehog system machinery controls transforming growth factor-b-dependent myofibroblastic differentiation in humans: involvement in idiopathic pulmonary fibrosis
Effects and mechanisms of pirfenidone, prednisone and acetylcysteine on pulmonary fibrosis in rat idiopathic pulmonary fibrosis models
PPAR-y ligands repress TGFb-induced myofibroblast differentiation by targeting the PI3K/Akt pathway: implications for therapy of fibrosis
WISP1 mediates IL-6-dependent proliferation in primary human lung fibroblasts
Melatonin attenuates TGFb1-induced epithelial-mesenchymal transition in lung alveolar epithelial cells
JAK2 mediates lung fibrosis, pulmonary vascular remodelling and hypertension in idiopathic pulmonary fibrosis: an experimental study
Ambroxol hydrochloride in the management of idiopathic pulmonary fibrosis: Clinical trials are the need of the hour
Reactive oxygen species are required for maintenance and differentiation of primary lung fibroblasts in idiopathic pulmonary fibrosis
MiR-5100 targets TOB2 to drive epithelial-mesenchymal transition associated with activating smad2/3 in lung epithelial cells
IL-17A deficiency mitigates bleomycin-induced complement activation during lung fibrosis
Inhibitory effect of receptor for advanced glycation end products (RAGE) on the TGF-b-induced alveolar epithelial to mesenchymal transition
Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) promotes lung fibroblast proliferation, survival and differentiation to myofibroblasts
TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease
Pleural mesothelial cell differentiation and invasion in fibrogenic lung injury
Absence of Thy-1 results in TGF-b induced MMP-9 expression and confers a profibrotic phenotype to human lung fibroblasts
Signalling pathways from NADPH oxidase-4 to idiopathic pulmonary fibrosis
Interplay between RAGE, CD44, and focal adhesion molecules in epithelial-mesenchymal transition of alveolar epithelial cells
Are mast cells instrumental for fibrotic diseases? Idiopathic pulmonary fibrosis (IPF) is a fatal lung disorder of unknown etiology characterized by accumulation of lung fibroblasts and extracellular matrix deposition, ultimately leading to compromised tissue architecture and lung function capacity
Association between cytokine removal by polymyxin B hemoperfusion and improved pulmonary oxygenation in patients with acute exacerbation of idiopathic pulmonary fibrosis
Increased production and immunohistochemical localization of transforming growth factor-beta in idiopathic pulmonary fibrosis
TNF-alpha, PDGF, and TGF-beta(1) expression by primary mouse bronchiolar-alveolar epithelial and mesenchymal cells: tnf-alpha induces TGF-beta(1)
Anchorage-independent colony growth of pulmonary fibroblasts derived from fibrotic human lung tissue
Overexpression of squamous cell carcinoma antigen in idiopathic pulmonary fibrosis: clinicopathological correlations
Intrinsic defence capacity and therapeutic potential of natriuretic peptides in pulmonary hypertension associated with lung fibrosis
Microsomal prostaglandin E synthase-1 deficiency exacerbates pulmonary fibrosis induced by bleomycin in mice
Antifibrotic effects of cyclosporine A on TGF-b1-treated lung fibroblasts and lungs from bleomycin-treated mice: role of hypoxia-inducible factor-1a
Preventive and therapeutic effects of thymosin b4 N-terminal fragment Ac-SDKP in the bleomycin model of pulmonary fibrosis
The role of halofuginone in fibrosis: more to be explored? Fibrosis, which can be defined as an abnormal or excessive accumulation of extracellular matrix (ECM), particularly fibrillar collagens, is a key driver of progressive organ dysfunction in many inflammatory and metabolic diseases, including idiopathic pulmonary fibrosis (IPF), cirrhosis, nephropathy, and oral submucous fibrosis (OSF)
Forkhead Box F1 (FOXF1) represses cell growth, COL1 and ARPC2 expression in lung fibroblasts in vitro
Nitrated fatty acids reverse pulmonary fibrosis by dedifferentiating myofibroblasts and promoting collagen uptake by alveolar macrophages
Serpin B4 isoform overexpression is associated with aberrant epithelial proliferation and lung cancer in idiopathic pulmonary fibrosis
Modulation of specific beta cell gene (re)expression during in vitro expansion of human pancreatic islet cells
Dehydroepiandrosterone has strong antifibrotic effects and is decreased in idiopathic pulmonary fibrosis
Regulation of the effects of TGF-beta 1 by activation of latent TGF-beta 1 and differential expression of TGF-beta receptors (T beta R-I and T beta R-II) in idiopathic pulmonary fibrosis
Establishment of the mouse model of acute exacerbation of idiopathic pulmonary fibrosis
CCN5 overexpression inhibits profibrotic phenotypes via the PI3K/Akt signaling pathway in lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis and in an in vivo model of lung fibrosis
Spiruchostatin A inhibits proliferation and differentiation of fibroblasts from patients with pulmonary fibrosis
Periostin promotes fibrosis and predicts progression in patients with idiopathic pulmonary fibrosis
Tumor necrosis factor superfamily 14 (LIGHT) controls thymic stromal lymphopoietin to drive pulmonary fibrosis
High levels of IL-6 and IL-8 characterize early-on idiopathic pulmonary fibrosis acute exacerbations
Mast cell chymase: an indispensable instrument in the pathological symphony of idiopathic pulmonary fibrosis? Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal lung disease with no known etiology and treatment options
Defect of pro-hepatocyte growth factor activation by fibroblasts in idiopathic pulmonary fibrosis
Lung infection with gamma-herpesvirus induces progressive pulmonary fibrosis in Th2-biased mice
Amplified canonical transforming growth factor-b signalling<i>via</i>heat shock protein 90 in pulmonary fibrosis
Pirfenidone attenuates bleomycin-induced pulmonary fibrosis in mice by regulating Nrf2/Bach1 equilibrium
Cytokine gene polymorphisms and serum cytokine levels in patients with idiopathic pulmonary fibrosis
Thalidomide prevents bleomycin-induced pulmonary fibrosis in mice
Reduced expression of BMP3 contributes to the development of pulmonary fibrosis and predicts the unfavorable prognosis in IIP patients
The antifibrotic effects and mechanisms of microRNA-26a action in idiopathic pulmonary fibrosis
The K+ channel KCa3.1 as a novel target for idiopathic pulmonary fibrosis
The Epstein-Barr virus latent membrane protein 1 and transforming growth factor--b1 synergistically induce epithelial--mesenchymal transition in lung epithelial cells
An inhibitor of NADPH oxidase-4 attenuates established pulmonary fibrosis in a rodent disease model
Pleiotropic effect of the proton pump inhibitor esomeprazole leading to suppression of lung inflammation and fibrosis
Activated human T lymphocytes inhibit TGFb-induced fibroblast to myofibroblast differentiation via prostaglandins D2 and E2
Peripheral depletion of NK cells and imbalance of the Treg/Th17 axis in idiopathic pulmonary fibrosis patients
Bone morphogenetic protein-4 inhibitor gremlin is overexpressed in idiopathic pulmonary fibrosis
Role of protease-activated receptor-2 in idiopathic pulmonary fibrosis
Type V collagen induced tolerance suppresses collagen deposition, TGF-b and associated transcripts in pulmonary fibrosis
Syndecan-2 is a novel target of insulin-like growth factor binding protein-3 and is over-expressed in fibrosis
Extracellular superoxide dismutase has a highly specific localization in idiopathic pulmonary fibrosis/usual interstitial pneumonia
Early growth response transcription factors: key mediators of fibrosis and novel targets for anti-fibrotic therapy
Effects of the tumor suppressor PTEN on the pathogenesis of idiopathic pulmonary fibrosis in Chinese patients
Different effects of growth factors on proliferation and matrix production of normal and fibrotic human lung fibroblasts
The impact of TGF-b on lung fibrosis: from targeting to biomarkers
Herpes virus infection is associated with vascular remodeling and pulmonary hypertension in idiopathic pulmonary fibrosis
N-acetylcysteine inhibits TNF-alpha, sTNFR, and TGF-beta1 release by alveolar macrophages in idiopathic pulmonary fibrosis in vitro
Recombinant human serum amyloid P in healthy volunteers and patients with pulmonary fibrosis
Transforming growth factor beta1 induces epithelial-to-mesenchymal transition of A549 cells
X-linked inhibitor of apoptosis regulates lung fibroblast resistance to Fas-mediated apoptosis
Idiopathic pulmonary fibrosis: immunohistochemical analysis provides fresh insights into lung tissue remodelling with implications for novel prognostic markers
PI3K p110y overexpression in idiopathic pulmonary fibrosis lung tissue and fibroblast cells: in vitro effects of its inhibition
Alveolar epithelial cell injury with Epstein-Barr virus upregulates TGFbeta1 expression
Expression of mucosa-related integrin alphaEbeta7 on alveolar T cells in interstitial lung diseases
Effects of cigarette smoke extract on A549 cells and human lung fibroblasts treated with transforming growth factor-beta1 in a coculture system
Nuclear factor erythroid 2-related factor 2 nuclear translocation induces myofibroblastic dedifferentiation in idiopathic pulmonary fibrosis
Rapamycin regulates connective tissue growth factor expression of lung epithelial cells via phosphoinositide 3-kinase
Peptide-mediated inhibition of mitogen-activated protein kinase-activated protein kinase-2 ameliorates bleomycin-induced pulmonary fibrosis
Effect of glycosides based standardized fenugreek seed extract in bleomycin-induced pulmonary fibrosis in rats: Decisive role of Bax, Nrf2, NF-kB, Muc5ac, TNF-a and IL-1b
Simvastatin inhibits growth factor expression and modulates profibrogenic markers in lung fibroblasts
Activated MCTC mast cells infiltrate diseased lung areas in cystic fibrosis and idiopathic pulmonary fibrosis
Type II alveolar epithelial cells and interstitial fibroblasts express connective tissue growth factor in IPF
Crosstalk between TGF-b1 and complement activation augments epithelial injury in pulmonary fibrosis
RhoA signaling modulates cyclin D1 expression in human lung fibroblasts; implications for idiopathic pulmonary fibrosis
Titration of non-replicating adenovirus as a vector for transducing active TGF-beta1 gene expression causing inflammation and fibrogenesis in the lungs of C57BL/6 mice
Age-driven developmental drift in the pathogenesis of idiopathic pulmonary fibrosis
Current and novel drug therapies for idiopathic pulmonary fibrosis
Proliferation of pulmonary interstitial fibroblasts is mediated by transforming growth factor-beta1-induced release of extracellular fibroblast growth factor-2 and phosphorylation of p38 MAPK and JNK
Secreted protein acidic and rich in cysteine (SPARC) is upregulated by transforming growth factor (TGF)-b and is required for TGF-b-induced hydrogen peroxide production in fibroblasts
Semaphorin 7a+ regulatory T cells are associated with progressive idiopathic pulmonary fibrosis and are implicated in transforming growth factor-b1-induced pulmonary fibrosis
Regulation of transforming growth factor-b1-driven lung fibrosis by galectin-3
Reduced transcription of the Smad4 gene during pulmonary carcinogenesis in idiopathic pulmonary fibrosis
Curcumin inhibits fibrosis-related effects in IPF fibroblasts and in mice following bleomycin-induced lung injury
Targeting sphingosine kinase 1 attenuates bleomycin-induced pulmonary fibrosis
Data on CUX1 isoforms in idiopathic pulmonary fibrosis lung and systemic sclerosis skin tissue sections
Arsenic trioxide inhibits transforming growth factor-b1-induced fibroblast to myofibroblast differentiation in vitro and bleomycin induced lung fibrosis in vivo