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  "TEXT": "The B cell-associated surface molecule CD40 functions to regulate B cell responses.",
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{
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  "TEXT": "Cross-linking CD40 on B cells can lead to homotypic cell adhesion, IL-6 production, and, in combination with cytokines, to Ig isotype switching.",
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  "POS ": "Cross-linking_NN CD40_NN on_IN B_NN cells_NNS can_MD lead_VB to_TO homotypic_JJ cell_NN adhesion_NN ,_, IL-6_NN production_NN ,_, and_CC ,_, in_IN combination_NN with_IN cytokines_NNS ,_, to_TO Ig_NN isotype_NN switching_NN ._. ",
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  "TEXT": "Tyrosine kinase activity is increased shortly after engagement of this receptor.",
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  "TEXT": "Little is known about how the very early events induced by CD40 cross-linking link to cellular responses.",
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  "TEXT": "In this study, we demonstrate that nuclear factor (NF)-kappa B and NF-kappa B-like transcription factors are activated after cross-linking CD40 on resting human tonsillar B cells and on B cell lines.",
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  "TEXT": "The complexes detected in electrophoretic mobility shift assays contain p50, p65 (RelA), c-Rel, and most likely other components.",
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  "TEXT": "By using transient transfection assays, we found that cross-linking CD40 supports NF-kappa B-dependent gene expression.",
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  "TEXT": "Our results define the NF-kappa B system as an intermediate event in CD40 signaling and suggest that the CD40 pathway can influence the expression of B cell-associated genes with NF-kappa B consensus sites.",
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