hilA expression is regulated by Salmonella invasion regulator ; however , it is not known how SirA is it known how sirA expression is itself regulated .
hilA expression is regulated by Salmonella invasion regulator ; however , it is not known how SirA modulates hilA expression .
hilA expression is regulated by SirA ; however , it is not known how SirA is it known how sirA expression is itself regulated .
hilA expression is regulated by SirA ; however , it is not known how SirA modulates hilA expression .
hilA expression is regulated by a protein ; however , it is not known how SirA is it known how sirA expression is itself regulated .
hilA expression is regulated by a protein ; however , it is not known how SirA modulates hilA expression .
Genes in SPI-5 are controlled by HilA , a transcriptional regulator by SirA , a regulator of hilA .
Genes in SPI-5 are controlled by HilA , a transcriptional regulator by SirA , a regulator of hilA .
Genes in SPI-4 are controlled by HilA , a transcriptional regulator by SirA , a regulator of hilA .
Genes in SPI-4 are controlled by HilA , a transcriptional regulator by SirA , a regulator of hilA .
SirA regulates hilA .
Although it has been proposed that SirA directly controls expression of both hilA , it was also determined that HilC was not required for SirA to control hilA expression .
Thus SirA controls expression of hilA .
Thus SirA controls expression of the three hilA regulators .
Previous attempts have been made to determine how SirA controls expression of hilA .
This genetic analysis is apparently inconsistent with previous gel shift data suggesting that SirA binds both hilA .
Once phosphorylated , SirA directly binds the hilA promoters .
SirA controls these genes by directly binding the hilA .
Conversely , previously published gel-shift data suggested that SirA is able to bind to the promoters of hilA .
Whereas SirA might bind to the hilA promoters during in-vitro gel-shift experiments , genetic data shows that SirA is incapable of directly activating these promoters ; SirA binding to DNA in-vitro does not represent activation .
SirA , directly regulates the hilA genes at the top of the invasion cascade .