Acquisition of the tviA gene by S. Typhi integrated the regulation of flagella into the RcsB regulons , such that flagellum expression is decreased following invasion of the intestinal mucosa , thereby avoiding detection by TLR5 present on the basolateral surface of CD11c dendritic cells in the lamina .
Acquisition of the tviA gene by S. Typhi integrated the regulation of flagella into the RcsB regulons , such that flagellum expression is decreased following invasion of the intestinal mucosa , thereby avoiding detection by TLR5 present on the basolateral surface of enterocytes dendritic cells in the lamina .
RcsB interacts with TviA to bind to the tviA promoter to activate the Vi antigen expression .