Fis represses transcription of the gyrB genes in E. coli .
Given the strong sequence similarity between the S. enterica gyrB gene , we anticipated that its promoter would show evidence of repression by Fis to a similar degree to approximately 1.5-fold .
Given the strong sequence similarity between the S. enterica gyrB gene , we anticipated that its promoter would show evidence of repression by Fis to a similar degree to that .
In E. coli , Fis-mediated repression of the gyrB promoter acts not through blocking of RNA polymerase binding but through interference with the formation of an open transcription complex by the bound polymerase .
the Fis protein is a repressor of gyrB transcription
In E. coli , FIS binds the gyrB promoters to repress their expression ; similarly , FIS has been found to repress S. enterica gyrB .