Under these conditions , however , the growth of phoP mutants was severely limited compared to the growth of wild-type bacteria ; thus , it was not clear if the decreased SsrAB-dependent gene expression in phoP mutants was due to direct regulation by PhoPQ effects on bacterial physiology .
the locus _ encoding the response regulator for the PhoPQ TCRS ( phoP ) gene
The unique pattern of expression of phoP was also found not to be attributable to coordinate regulation by PhoPQ ( not shown ) .
Expression of the phoP gene was not increased in intracellular bacteria , although we did observe the expected PhoPQ-regulated control of PhoP-activated genes ( examples include genes ) .
Expression of the phoP gene was not increased in intracellular bacteria , although we did observe the expected PhoPQ-regulated control of PhoP-activated genes ( pag include genes ) .
The isogenic phoP tolC strain showed intermediate permeability , as expected from the fact that some of the PhoPQ-regulated modification reactions , especially the palmitoylation of lipid-A , occur in the wild-type strain to a considerable extent ( 21 ) .
The failure of the phoP mutant to survive in A. polyphaga cells further supports the theory that survival within survival within macrophages are largely analogous , as the PhoPQ two-component regulatory system , although associated with regulation of many genes , is key to activation of the SPI-2-encoded T3SS within phagocytes .
The failure of the phoP mutant to survive in A. polyphaga cells further supports the theory that survival within amoebae within macrophages are largely analogous , as the PhoPQ two-component regulatory system , although associated with regulation of many genes , is key to activation of the SPI-2-encoded T3SS within phagocytes .
Both S. Typhi PhoPQ directly control expression of phoP itself , .
phoP genes _ controlled by the PhoPQ TCS