Consistent with the role of FimZ as an activator of S. typhimurium fimA expression , fimZ mutants exhibit only low levels of fimA expression .
Consistent with the role of FimZ as an activator of S. typhimurium fimA expression , fimZ mutants are non-fimbriate .
Since FimZ are both required to activate fimA , it is possible that these two proteins form a complex to bind the promoter of fimA .
We demonstrated that FimZ is a transcriptional activator of fimA .