The expression of hilA is itself controlled by two additional SPI-1 regulators : HilC .
HilC bind the same regions upstream of hilA .
In addition to binding upstream of hilA , HilC also bind to sites upstream of hilC .
In addition to binding upstream of hilA , HilC also bind within S. Akbar , unpublished results .
In addition to binding upstream of hilA , HilC also bind within the prgH-hilD intergenic region .
HilC are positive regulators of hilA expression
HilC have been shown to bind to URS of hilA .
HilC have been shown to bind to the upstream repressing sequence of hilA .
HilC bind directly to the upstream sequence of hilA .
HilC can independently bind the hilA promoter .
a model in which expression of hilA is controlled by the combined action of HilC
a model in which expression of hilA is controlled by the combined action of HilC
This is consistent with the feedforward loop model ; when neither HilC are present , regulation of hilA is dampened , even though the primary signal is mediated through HilD .
HilC bind to overlapping sites in the hilA promoter .
Lee , C.A. Roles of HilC in regulation of hilA expression in Salmonella enterica sero-var Typhimurium .
Studies have shown PheU that HilC can each individually bind to the hilA promoter
HilC , in addition to regulation of hilA , are all capable of inducing expression of the inv/spa operon -- and by the sic/sip operon -- in a fashion independent of HilA .
HilC , in addition to regulation of hilA , are all capable of inducing expression of the inv/spa operon -- and by read-through -- in a fashion independent of HilA .
This work demonstrates the regulation of hilA by HilC .
HilC were described to influence the expression of hilA .
SCHECHTER L.M. , LEE C.A. : HilC , directly bind the Salmonella typhimurium hilA promoter .
Transcription from the hilA promoter is in turn mainly regulated by three transcription factors ; HilC .
Earlier work on mathematical modeling of regulation of expression of hilA by HilC was based on feed-forward architecture , considering HilD to be the primary activator of the feed-forward loop .
The results of these surveys can be summarized as follows : i. Dam-dependent regulation of hilA was not abolished in the absence of HilC .
The results of these surveys are shown in Figure 3 : i. Dam-dependent regulation of hilA was not abolished in the absence of HilC .
In turn , hilA is regulated by HilC .
Schechter LM , Lee CA : HilC , directly bind the Salmonella typhimurium hilA promoter .
HilC mutually regulate the hilA gene expression 2 1 1 0 Control SGJ-3 SGJ-4 SGJ-5 0 SGJ-4 SGJ-3 Control SGJ-5 Fig. 3 Invasive ability of lysogenic S. Typhimurium , SgJ-4 , and SgJ-5 for 30 min in InT-407 cells .
HilC mutually regulate the hilA gene expression 2 1 1 0 Control SGJ-3 SGJ-4 SGJ-5 0 SGJ-4 SGJ-3 Control SGJ-5 Fig. 3 Invasive ability of lysogenic S. Typhimurium , SgJ-4 , and pH 5 for 30 min in InT-407 cells .
HilC mutually regulate the hilA gene expression 2 1 1 0 Control SGJ-3 SGJ-4 SGJ-5 0 SGJ-4 SGJ-3 Control SGJ-5 Fig. 3 Invasive ability of lysogenic S. Typhimurium , pH 4 , and SgJ-5 for 30 min in InT-407 cells .
HilC mutually regulate the hilA gene expression 2 1 1 0 Control SGJ-3 SGJ-4 SGJ-5 0 SGJ-4 SGJ-3 Control SGJ-5 Fig. 3 Invasive ability of lysogenic S. Typhimurium , pH 4 , and pH 5 for 30 min in InT-407 cells .
Differential expression of hilA , is influenced by HilC
Expression of hilA is directly controlled by SPI-1-encoded HilC and HilD
LoiA activates expression of hilA gene through activating hilD As the expression of hilA is directly controlled by HilC , we tested whether LoiA regulates HilA through any of these three regulators .