Previous work has shown that the global transcription factors FNR and CRP positively regulate hlyE expression by binding at the same site .
Previous studies have shown that FNR contribute to hlyE expression when E. coli is grown on a solid medium .
Thus , we concluded that FNR all contribute towards the regulation of hlyE expression .
Footprinting studies have shown that FNR activate hlyE expression from the same site centered 61.5 bp upstream of the SlyA-associated transcription start site .
This reciprocity of transcriptional efficiency provides a mechanism for the moderate upregulation of hlyE expression in response to two distinct environmental signals rather than , for the much larger degree of upregulation when FNR act synergistically by binding at different sites within the ansB promoter .
This reciprocity of binding site recognition provides a mechanism for the moderate upregulation of hlyE expression in response to two distinct environmental signals rather than , for the much larger degree of upregulation when FNR act synergistically by binding at different sites within the ansB promoter .
This reciprocity of transcriptional efficiency provides a mechanism for the moderate upregulation of hlyE expression in response to glucose-starvation rather than , for the much larger degree of upregulation when FNR act synergistically by binding at different sites within the ansB promoter .
This reciprocity of transcriptional efficiency provides a mechanism for the moderate upregulation of hlyE expression in response to oxygen rather than , for the much larger degree of upregulation when FNR act synergistically by binding at different sites within the ansB promoter .
This reciprocity of binding site recognition provides a mechanism for the moderate upregulation of hlyE expression in response to glucose-starvation rather than , for the much larger degree of upregulation when FNR act synergistically by binding at different sites within the ansB promoter .
This reciprocity of binding site recognition provides a mechanism for the moderate upregulation of hlyE expression in response to oxygen rather than , for the much larger degree of upregulation when FNR act synergistically by binding at different sites within the ansB promoter .
In E. coli , global transcription factors FNR and CRP positively regulate hlyE expression by binding at the same site at the promoter region in response to oxygen depletion and glucose-starvation , respectively .