A novel NsrR-regulated gene designated STM1808 has been identified , along with hmp , hcp-hcr , yeaR-yoaG , ygbA and ytfE .
To determine the contribution of other NsrR-regulated genes to nitrosative-stress resistance , we constructed insertion mutations in hcp , ygbA , ytfE , STM1808 and yeaR ( Experimental Procedures ) .
These data confirm previous findings with regard to hmp , and additionally demonstrate that the NsrR-regulated ytfE and STM1808 genes contribute to Salmonella virulence .
We have identified a novel NsrR-regulated gene designated STM1808 , and demonstrated a role for specific NsrR-regulated genes in promoting growth during nitrosative-stress in-vitro ( hmp , STM1808 , ygbA and hcp ) and during systemic infection of mice in-vivo ( hmp , STM1808 , ytfE ) .
We have identified a novel NsrR-regulated gene designated STM1808 , and demonstrated a role for specific NsrR-regulated genes in promoting growth during nitrosative-stress in-vitro ( hmp , STM1808 , ygbA and hcp ) and during systemic infection of mice in-vivo ( hmp , STM1808 , ytfE ) .
STM1808 and ytfE can be added to hmp as NsrR-regulated loci that contribute to Salmonella virulence ( Fig. 6 ) .
Our findings include the identification of a novel NsrR-regulated gene ( STM1808 ) that is important for nitrosative-stress resistance and virulence in mice .
These include the NsrR-regulated ygbA , yeaR-yoaG and STM1808 genes ( Bang , 2006 ; Gilberthorpe et al. , 2007 ; Karlinsey et al. , 2012 ; Rodionov et al. , 2005 ) .
STM1808 is regulated by NsrR , whilst STM1808 mutants have a growth impairment upon exposure to NO .