Here we report that YgaE is a repressor of ompC in S. Typhi ; it can be partially explained why the expression of ompC is not up-regulated under hyperosmotic-stress .
The repression of YgaE to ompC means less pathways for antibiotics .
The repression of YgaE to ompC means less pathways for nutrition .
One explanation for these phenomena is the repression of YgaE to ompC occurs only in the very early stage of hyperosmotic-stress as an emergency approach to protect the bacteria .
As time goes by , other mechanisms are involved in the process of handling the hyperosmotic-stress , the repression of YgaE to ompC relieves .
the expressions of ompC were obviously repressed by YgaE at the early stage