In accordance with apparent phosphod-iesterase activity in-vivo , the absence of STM4264 significantly activated CsgD expression whereby 361 STM1703 particularly was also required for temperature regulation of the rdar morphotype .
Overcoming the temperature regulation of Salmonella serovar Typhimurium UMR1 by mutations in STM4264 demonstrated that both gene products act as suppressors of the rdar morphotype expression upstream of CsgD at 37 °C .
Consequently , STM1344 acts upstream of STM3611 in the regulation of CsgD , whereas STM1344 is either located downstream of STM4264 .
Consequently , STM1344 acts upstream of STM1703 in the regulation of CsgD , whereas STM1344 is either located downstream of STM4264 .