CueR is known to be a copper-responsive transcriptional regulator of the copA gene .
copA is shown here to be transcriptionally controlled by CueR
Expression of copA in Salmonella is directly controlled by CueR Unlike in E. coli , in Salmonella copA are located adjacent in the genome .
Expression of copA in Salmonella is directly controlled by CueR Unlike in E. coli , in Salmonella cueR are located adjacent in the genome .
To confirm that copA transcription in Salmonella is controlled directly by the transcriptional regulator CueR , we first mapped the transcription start site of the gene by primer-extension analysis , using RNA .
CueR binds to the promoter region of copA .
Among these , we identified the GolS-target operators from the golTS operon and the golB gene ( Checa et al. , 2007 ) , as well as the CueR-controlled operators from cueO and copA genes ( Kim et al. , 2002 ; Espariz et al. , 2007 ) .
CueR regulates copA .