Induction of heme synthesis during oxidative-stress seems reasonable because OxyR also induces the synthesis of hydroperoxidase I. Nevertheless , the reduction in hemA mRNA levels while the hemH mutant is activated suggests that during oxidative-stress it may be important to simultaneously shut off the heme synthesis pathway at its first step , while completing the conversion of potentially toxic intermediate products into heme .
Induction of heme synthesis during oxidative-stress seems reasonable because OxyR also induces the synthesis of hydroperoxidase I. Nevertheless , the reduction in hemA mRNA levels while the hemH mutant is activated suggests that during oxidative-stress it may be important to simultaneously shut off the heme synthesis pathway at its first step , while completing the conversion of potentially toxic intermediate products into heme .
Induction of heme synthesis during oxidative-stress seems reasonable because OxyR also induces the synthesis of a major heme-requir-ing enzyme Nevertheless , the reduction in hemA mRNA levels while the hemH mutant is activated suggests that during oxidative-stress it may be important to simultaneously shut off the heme synthesis pathway at its first step , while completing the conversion of potentially toxic intermediate products into heme .