This paper is available on line at http://www.jbc.org 9083 PhoP-activated gene pagP ( 29 ) .
The PhoP-activated ugtL , pagP and yqjA genes are required for resistance to the alpha-helical peptides magainin 2 and cecropin A but not to the b-sheet defensin HNP-1 .
Thus , we investigated the role of the PhoP-activated pagP and pgtE genes , because they had been implicated in resistance to the alpha-helical peptide C18G ( Guo et al. , 1998 ; Guina et al. , 2000 ) .
Cumulatively , these results demonstrate that yqjA is a PhoP-activated gene required for magainin 2 resistance and that yqjA confers magainin resistance by a pathway that is different from those mediated by the ugtL and pagP genes .
PhoP-suppressed genes include prgH and fliC [ 55 -- 57 ] , PhoP-activated genes include pmrAB , another two-component signal transduction system involved primarily in the protection of Salmo-nella to cationic antimicrobial peptides ( CAMP , see below ) [ 58 ] , mgtA and mgtCB encoding Mg transport 2 + systems , phoN , a periplasmic non-specific acid phospha-tase , pcgL encoding a periplasmic D-Ala -- D-Ala dipeptidase , or pagL , pagP and pgtE which contribute to increased resistance to CAMPs [ 59 -- 62 ] .