pH coordinately affect the transcription of hilA in the level of HilA mediate the regulation of TTSS-1 by the same environmental conditions .
oxygen coordinately affect the transcription of hilA in the level of HilA mediate the regulation of TTSS-1 by the same environmental conditions .
Osmolarity coordinately affect the transcription of hilA in the level of HilA mediate the regulation of TTSS-1 by the same environmental conditions .
Although a great deal is known about the complex regulation of hilA gene expression , very little is known about the HilA protein .
Genes in SPI-5 are controlled by HilA , a transcriptional regulator by SirA , a regulator of hilA .
Genes in SPI-4 are controlled by HilA , a transcriptional regulator by SirA , a regulator of hilA .
HilA is the key regulator of the Salmonella Pathogenicity Island I. To assess the role of hilA in internal organs in poultry , animals were infected with 10 CFU of its parent strain at day of hatch .
HilA is the key regulator of the Salmonella Pathogenicity Island I. To assess the role of hilA in internal organs in poultry , animals were infected with 10 CFU of a DhilA mutant of S. 8 Enteritidis .
HilA is the key regulator of the Salmonella Pathogenicity Island I. To assess the role of hilA in colonization of gut , animals were infected with 10 CFU of its parent strain at day of hatch .
HilA is the key regulator of the Salmonella Pathogenicity Island I. To assess the role of hilA in colonization of gut , animals were infected with 10 CFU of a DhilA mutant of S. 8 Enteritidis .
3 s 4 Model 2 : Two feedforward loops with OR gate logic for regulation of P by monomer hilA activation ðModel 4Þ s 5 1/2 6 a3 HilA : ðModel 2Þ e activators are set to 2 , the the activation of PhilA by If Hill coefficients of all th model generated represents homodimers .
The X-axis shows the time in arbitrary units while the Y-axis shows the level of HilA in arbitrary units Comparison of P regulation by AND and OR hilA architectures .
As HilA is an important transcriptional regulator of SPI-1 , Bohez et al. discovered that Salmonella with hilA mutant is the promising vaccines due to its remarkable role in reducing colonization .
As HilA is an important transcriptional regulator of SPI-1 , Bohez et al. discovered that Salmonella with hilA mutant is the promising vaccines due to its remarkable role in reducing invasion .
Differential expression of the hilA gene The HilA protein is the master regulator of SPI-1 typically decrease on invasion .
Differential expression of the hilA gene The HilA protein is the master regulator of SPI-1 typically have a corresponding increase .
However , RNA-seq data from a hilA strain with/without transient overexpression of HilA were consistent with regulation of transcripts within SPI-1 .
Our data show that Gre factors are involved in the transcriptional expression of both hilA and HilA-regulated genes .
Expression of the SPI-1 master regulatory gene hilA and five HilA-regulated SPI-1 genes ( sipB , spaO , invH , prgH and invF ) was tested in the loiA mutant , in comparison with the wild-type strain , grown under SPI-1-inducing conditions ( low O2 , high salt ) .
We can infer that this negative regulation is a consequence of SlyA binding to the hilA promoter region ( Fig. 4C ) , which affects the expression of all HilA-regulated genes in a downstream cascade .