The aim of the present study was to identify the molecular mechanisms of CadC-mediated transcriptional repression of ompR .
These findings reveal a previously un recognized regulatory mechanism by which CadC represses autoinduction of the ompR gene .
Discussion Inverse correlation between the response regulator OmpR S. enterica serovar Typhimurium CadC is known to act as a repressor of ompR transcription during acid adaptation .
Discussion Inverse correlation between the acid-sensing regulator CadC CadC is known to act as a repressor of ompR transcription during acid adaptation .
CadC interacts directly with OmpR Since S. enterica serovar Typhimurium OmpR response re-gulator was shown to induce its own synthesis by binding to its promoter , we hypothesized that CadC could mediate the repression of ompR gene expression by direct interaction with OmpR , sterically hindering binding of OmpR to RNA polymerase .
CadC interacts directly with OmpR Since S. enterica serovar Typhimurium OmpR response re-gulator was shown to induce its own synthesis by binding to its promoter , we hypothesized that CadC could mediate the repression of ompR gene expression by direct interaction with OmpR , sterically hindering binding of OmpR to its own promoter .
Since our data clearly demonstrated CadCmediated repression of ompR gene expression , we speculated that CadC may be involved in the control of motility , at least during acid adaptation .
Since our data clearly demonstrated CadCmediated repression of ompR gene expression , we speculated that CadC may be involved in the control of fla-gellation , at least during acid adaptation .
a possible mechanism _ underlying the CadC-mediated repression of ompR autoinduction
a possible mechanism _ underlying the CadC-mediated repression of ompR autoinduction