Recent studies indicate that HilA binds to specific sequences in the invF promoters .
By placing invF encoding the secretion machinery under direct control of HilA , S. typhimurium ensures that secreted the secretion apparatus are produced simultaneously .
By placing invF encoding the secretion machinery under direct control of HilA , S. typhimurium ensures that secreted effectors are produced simultaneously .
Fis affects expression of invF : : Tn5lacZY in the absence of HilA Current models for the regulation of invasion genes suggest that there is a HilA-independent pathway to invF expression .
These results indicate that Fis is also involved in the regulation of invF expression in a HilA-independent manner .
It will be interesting to determine how the binding of HilA upstream of invF affects the ability of HilC to activate invF .
It will be interesting to determine how the binding of HilA upstream of invF affects the ability of HilC to bind upstream of .
It will be interesting to determine how the binding of HilA upstream of invF affects the ability of HilD to activate invF .
It will be interesting to determine how the binding of HilA upstream of invF affects the ability of HilD to bind upstream of .
HilA activates invF operon expression by binding to the invF promoter .
Transcription of invF is primarily regulated by HilA
Dam-dependent regulation of invF was still observed in HilA
The invF gene is regulated by the HilA protein .
Expression of the SPI-1 master regulatory gene hilA and five HilA-regulated SPI-1 genes ( sipB , spaO , invH , prgH and invF ) was tested in the loiA mutant , in comparison with the wild-type strain , grown under SPI-1-inducing conditions ( low O2 , high salt ) .
Additionally , HilA can bind to specific sequences in the promoter of invF , a transcriptional regulator .