Although the STM4264 mutant showed the highest c-di-GMP concentration , CsgD expression was lower than in the STM1703 mutant .
STM4264 is located upstream of STM1703 , since STM1703 can complement an STM4264 defect by downregulation of CsgD versa .
STM1344 favors sessility by repressing the expression of the two phosphodiesterases , STM1703 , required for the downregulation of CsgD expression .
STM1344 positively affects the expression of the major regulator of CsgD , through the downregulation of the expression of the phosphodiesterases STM1703 and STM3611 .
STM1703 inhibit CsgD function .
During growth on low salt agar plates , STM1703 is the major inhibitor of CsgD , while the other three PDEs play more minor roles .