Two reports have shown that prgH expression , can be upregulated by artificially expressing high levels of HilC even in the absence of hilA .
Two reports have shown that invF expression , can be upregulated by artificially expressing high levels of HilC even in the absence of hilA .
the key regulator hilA , we have focused on two activators of HilC .
HilC can independently activate the hilA promoter .
These data suggest that HilC may activate hilA expression in response to a set of signals .
We wanted to determine if HilC could induce expression of hilA in the absence of the other regulators .
The data in Fig. 2 demonstrate that HilC are able to induce expression of hilA in the absence of the other regulators .
We show that HilC can each independently activate expression of the hilA genes .
However , HilC normally act in concert to activate hilA .
Olekhnovich , I.N. , and Kadner , R.J. Contribution of the RpoA C-terminal domain to stimulation of the Salmo-nella enterica hilA promoter by HilC .
Olekhnovich , I.N. , and Kadner , R.J. Contribution of the RpoA C-terminal domain to stimulation of the Salmo-nella enterica hilA promoter by HilC .
8,13,14 HilC can activate expression of hilA .
Contribution of the RpoA C-terminal domain to stimulation of the Salmonella enterica hilA promoter by HilC .
Contribution of the RpoA C-terminal domain to stimulation of the Salmonella enterica hilA promoter by HilC .
The mechanism by which HilC activate expression of hilA
That means that at least hilA are induced by HilC .
Under high-osmolarity conditions , HilC activate SPI1 genes indirectly through hilA .
Under high-osmolarity conditions , HilC activate SPI1 genes directly through hilA .
Contribution of the RpoA C-terminal domain to stimulation of the Salmonella enterica hilA promoter by HilC .
Contribution of the RpoA C-terminal domain to stimulation of the Salmonella enterica hilA promoter by HilC .
HilC are each capable of activating hilA transcription .
Earlier work on mathematical modeling of regulation of expression of hilA by HilC was based on feed-forward architecture , considering HilD to be the primary activator of the feed-forward loop .
HilC are central activators of hilA expression ( Ellermeier et al. , 2005 ; 2001 ; Schechter et al. , Abbreviations : Cy , Cyanine ; SSC , saline sodium citrate ; SPI1 , Salmonella pathogenicity island 1 ; S. Typhimurium , Salmonella enterica serovar Typhimurium ; TTSS , type III secretion system .
HilC are central activators of hilA expression ( Ellermeier et al. , 2005 ; Lee ; Schechter et al. , Abbreviations : Cy , Cyanine ; SSC , saline sodium citrate ; SPI1 , Salmonella pathogenicity island 1 ; S. Typhimurium , Salmonella enterica serovar Typhimurium ; TTSS , type III secretion system .
HilC are central activators of hilA expression ( Ellermeier et al. , 2005 ; Lucas ; Schechter et al. , Abbreviations : Cy , Cyanine ; SSC , saline sodium citrate ; SPI1 , Salmonella pathogenicity island 1 ; S. Typhimurium , Salmonella enterica serovar Typhimurium ; TTSS , type III secretion system .
hilA expression is induced by three transcriptional activators , HilC .
Transcription of hilA is directly activated by HilC .
Inducible expression HilC protein was sufficient to activate hilA following growth at 42 °C .
HilC , activate directly the expression of hilA , independently of HilA .