In contrast , inactivation of just the hupB gene correlated with the upregulation of members of the RpoS regulon in exponential-phase cultures .
Here , inactivation of hupA resulted in the downregulation of many RpoS-dependent genes while the hupB mutation caused the same genes to be expressed at a higher level .
Here , inactivation of hupA resulted in the downregulation of many RpoS-dependent genes while the hupB mutation caused the same genes to be expressed at a higher level .