The PhoP/PhoQ regulatory system has been shown to regulate the expression of a variety including pagC .
The PhoP/PhoQ regulatory system has been shown to regulate the expression of pagC .
Because PhoP/PhoQ regulates more than 40 genes , additional PhoP/PhoQ-activated genes , including pmrD and pagD , were examined to determine if bile specifically regulated pagC , or if it has a general effect on PhoP/PhoQ-regulated genes .
The results establish that other PhoP/PhoQ-regulated genes were unaffected by the presence of bile ( as exemplified by pagD and pmrD , Fig. 2 ) , suggesting that pagC is specifically affected by bile .
pagC was originally identified as a PhoP/PhoQ-regulated gene required for S. Typhimurium virulence in a mouse model and for its survival within macrophages ( Miller et al. , 1989 ) .
pagC is a macrophage-inducible promoter is controlled by the PhoP/PhoQ two-component regulatory system .
recombinants express these genes under the control of the macrophage-inducible pagC promoter , controlled by the PhoP/PhoQ two-component regulatory system has been found to be an effective in-vivo-inducible promoter when compared to others
recombinants express these genes under the control of the macrophage-inducible pagC promoter , controlled by the PhoP/PhoQ two-component regulatory system has been found to be an effective in-vivo-inducible promoter when compared to others
The PhoP-activated gene pagC _ regulated by the PhoP/PhoQ system