While normally repressed by MarR , a mutation within the marO genes leads to constitutive transcriptional activation of marRAB , resulting in increased drug resistance .
While normally repressed by MarR , a mutation within the marR genes leads to constitutive transcriptional activation of marRAB , resulting in increased drug resistance .
The repressor MarR , binds to the marO operator region to negatively regulate expression of marRAB .
MarR inhibits binding of MarR to the marRAB promoter
MarR negatively regulates expression of marRAB by binding to the marO operator region .
MarR negatively regulates the expression of marRAB by binding to the marO operator region .
Thus induction of marRAB by DEC without inhibition of the repression activity of MarR is expected to be less effective than induction with SAL .