Fur repressed ssrB expression both under acidic conditions , which we ascribe to the direct binding of Fur to the ssrB promoter .
Fur repressed ssrB expression both inside macrophages , which we ascribe to the direct binding of Fur to the ssrB promoter .
We reveal that Fur provide evidence that Fur represses SsrB production by binding to the ssrB promoter .
The Fur regulator directly binds to the ssrB promoter .
Based on this finding , we explored whether the Fur regulator could directly bind to the ssrB promoter .
We further reasoned that if Fur controls SPI-2 genes via the repression of ssrB transcription , Fur repression of SPI-2 expression would be impaired when the ssrB gene is ectopically expressed from a heterologous promoter .
FIG 4 The Fur regulator directly binds to the ssrB promoter .
We determined that Fur represses ssrB transcription by directly binding to the ssrB promoter .
Because the putative 19-bp Fur box is located only 5 bp because Fur binds to regions larger than the Fur box , it is possible that the Fur repressor competes with the SsrB activator for binding to the ssrB promoter .
Because the putative 19-bp Fur box is located only 5 bp upstream of the SsrB binding site on Fig. 4A binds to regions larger than the Fur box , it is possible that the Fur repressor competes with the SsrB activator for binding to the ssrB promoter .
Because the putative 19-bp Fur box is located only 5 bp upstream of the SsrB binding site on the ssrB promoter binds to regions larger than the Fur box , it is possible that the Fur repressor competes with the SsrB activator for binding to the ssrB promoter .