Fur repressed ssrB expression both under acidic conditions , which we ascribe to the direct binding of Fur to the ssrB promoter .
Fur repressed ssrB expression both inside macrophages , which we ascribe to the direct binding of Fur to the ssrB promoter .
We reveal that Fur provide evidence that Fur represses SsrB production by binding to the ssrB promoter .
Fur represses expression of the ssrB gene .
Fur negatively controls SPI-2 expression via repression of ssrB transcription .
Fur negatively controls SPI-2 expression via repression of ssrB transcription .
Given that that Fur represses ssrB expression , it is possible that the Fur regulator controls SPI-2 genes in a fashion dependent on the SsrB regulator .
We further reasoned that if Fur controls SPI-2 genes via the repression of ssrB transcription , Fur repression of SPI-2 expression would be impaired when the ssrB gene is ectopically expressed from a heterologous promoter .
We further reasoned that if Fur controls SPI-2 genes via the repression of ssrB transcription , Fur repression of SPI-2 expression would be impaired when the ssrB gene is ectopically expressed from a heterologous promoter .
We further reasoned that if Fur controls SPI-2 genes via the repression of ssrB transcription , Fur repression of SPI-2 expression would be impaired when the ssrB gene is ectopically expressed from a heterologous promoter .
Taken together , these results illustrate that Fur repression of ssrB transcription leads to repression of SPI-2 genes under acidic conditions .
Taken together , these results illustrate that Fur repression of ssrB transcription leads to repression of SPI-2 genes under acidic conditions .
FIG 3 The Fur regulator represses expression of the ssrB gene under acidic conditions .
FIG 3 The Fur regulator represses expression of the ssrB gene inside macro-phages .
We determined that Fur represses ssrB transcription by directly binding to Fig. 4B .
We determined that Fur represses ssrB transcription by directly binding to the ssrB promoter .
We determined that Fur represses ssrB transcription by directly binding to the ssrB promoter .
FIG 5 Fur repression of ssrB expression leads to repression of SPI-2 expression .
FIG 5 Fur repression of ssrB expression leads to repression of SPI-2 expression .