A positive regulator , TviA ( VipR ) , activates its own synthesis by binding upstream of the tviA promoter [ 27 ] and interacts with RcsB to promote optimal transcription of genes involved in Vi antigen synthesis [ 24 , 25 , 28 , 29 ] .
a DphoN : : tviA mutant were grown in tryptone yeast extract broth containing 0.3 M NaCl and subsequently transferred into tissue culture medium Expression of tviA in S. Typhimurium results in increased translocation to the spleen in a chicken model By evading detection through sentinels of the intestinal immune system , TviA-mediated flagellin repression might prevent induction of mucosal barrier functions orchestrated by proinflammatory signals .
A S. Typhimurium DphoN mutant : : tviA mutant were grown in tryptone yeast extract broth containing 0.3 M NaCl and subsequently transferred into tissue culture medium Expression of tviA in S. Typhimurium results in increased translocation to the spleen in a chicken model By evading detection through sentinels of the intestinal immune system , TviA-mediated flagellin repression might prevent induction of mucosal barrier functions orchestrated by proinflammatory signals .
We reasoned that this comparison would allow us to disentangle the contribution of the Vi capsular polysaccharide from the contribution of TviA , since a simple deletion of tviA is pleiotropic and would affect Vi fliC expression simultaneously .
We reasoned that this comparison would allow us to disentangle the contribution of the Vi capsular polysaccharide from the contribution of TviA , since a simple deletion of tviA is pleiotropic and would affect Vi fliC expression simultaneously .
We reasoned that this comparison would allow us to disentangle the contribution of the Vi capsular polysaccharide from the contribution of TviA , since a simple deletion of tviA is pleiotropic and would affect Vi capsular polysaccharide expression simultaneously .
We reasoned that this comparison would allow us to disentangle the contribution of the Vi capsular polysaccharide from the contribution of TviA , since a simple deletion of tviA is pleiotropic and would affect Vi capsular polysaccharide expression simultaneously .