"agent: 1x vehicle"	"characteristics_ch1.1"
"75th percentile shift normalisation and baseline adjusted"	"data_processing.1"
"RNA isolation was performed using an RNeasy mini kit (Qiagen Technologies, Hilden, Germany), according to the manufacturer’s protocol. DNA decontamination treatment was performed using Turbo DNase (Qiagen) and the quantity and purity of the purified RNA samples were determined using a spectrophotometer Nanodrop-1000 (Nanodrop Technologies Inc., Wilmington, DE, USA) by measuring the absorbance (A260, 230, 280) and calculating absorbance ratios (A260/A230 and A260/A280). All samples had A260/A230 and A260/A280 ratios above 1.9. The RNA integrity was analysed using Agilent 2100 Bioanalyzer (Agilent Technologies, Palo Alto, CA, USA) in conjunction with RNA 6000 Nano LabChip kit (Agilent Technologies) according to the manufacturer’s protocol. RNA integrity number (RIN) values were > 8.5 for all samples."	"extract_protocol_ch1.1"
"Cultures were maintained on tryptic soy agar (TSA) (Becton Dickinson, Le Pont Claix, France). Overnight cultures were grown in Difco Luria-Bertani (LB) broth (Lennox; Franklin Lakes, NJ, USA) at 37 °C aerobically on a shaker at 200 rpm. Bacteria (picked from 5-10 colonies) were suspended in 1 ml of PBS, yielding a suspension corresponding to the turbidity of McFarland 0.5, and diluted 1:100 in minimal salt (MS)-medium (~106 CFU/ml). The suspension was exposed to CORM-2 (250 µM) or vehicle (2.5% DMSO) for 4 hours at 37 °C. A volume (10 µl) was spread onto TSA-agar plates and incubated at 37 °C overnight. This procedure was repeated 10 times (10x, ~45 generations) or 20 times (20x, ~90 generations)."	"growth_protocol_ch1.1"
"Escherichia coli"	"organism_ch1.1"
"E.coli-1x vehicle-rep4"	"source_name_ch1.1"
"E.coli-1x vehicle-rep4"	"title.1"
"Overnight cultures of ESBL7 from the original isolate, or isolates pre-exposed 20 times to CORM-2 or vehicle, were used to inoculate MS-medium, (OD620) of 0.1, followed by exposure to CORM-2 (250 µM) or vehicle for 30 min at 37 °C."	"treatment_protocol_ch1.1"
"agent: 1x vehicle"	"characteristics_ch1.1"
"Cultures were maintained on tryptic soy agar (TSA) (Becton Dickinson, Le Pont Claix, France). Overnight cultures were grown in Difco Luria-Bertani (LB) broth (Lennox; Franklin Lakes, NJ, USA) at 37 °C aerobically on a shaker at 200 rpm. Bacteria (picked from 5-10 colonies) were suspended in 1 ml of PBS, yielding a suspension corresponding to the turbidity of McFarland 0.5, and diluted 1:100 in minimal salt (MS)-medium (~106 CFU/ml). The suspension was exposed to CORM-2 (250 µM) or vehicle (2.5% DMSO) for 4 hours at 37 °C. A volume (10 µl) was spread onto TSA-agar plates and incubated at 37 °C overnight. This procedure was repeated 10 times (10x, ~45 generations) or 20 times (20x, ~90 generations)."	"growth_protocol_ch1.1"
"Escherichia coli"	"organism_ch1.1"
"E.coli-1x vehicle-rep4"	"source_name_ch1.1"
"Overnight cultures of ESBL7 from the original isolate, or isolates pre-exposed 20 times to CORM-2 or vehicle, were used to inoculate MS-medium, (OD620) of 0.1, followed by exposure to CORM-2 (250 µM) or vehicle for 30 min at 37 °C."	"treatment_protocol_ch1.1"