"sample type: control"	"characteristics_ch1.1"
"sample type: test"	"characteristics_ch2.1"
"Scanned images were analyzed with GenePix Pro 3.0 software (Axon Instruments, Union City, CA) to obtain gene expression ratios. Logged gene expression ratios were normalized by LOWESS regression (Yang et al., 2002) using the GeneSpring GX 7.3 software (Agilent Technologies)."	"data_processing.1"
"Transcriptome of cells was prepared using a RNA extraction kit (RNeasy mini kit;Qiagen, Hilden, Germany)"	"extract_protocol_ch1.1"
"Transcriptome of cells was prepared using a RNA extraction kit (RNeasy mini kit;Qiagen, Hilden, Germany)"	"extract_protocol_ch2.1"
"The medium for continuous culture contained 3 g glucose medium consisted with 0.8 g NH4Cl, 0.5 g NaCl, 7.5 g Na2HPO4•2H2O, 3 g KH2PO4 with separately added trace element of 0.2 g MgSO4•7H2O, 0.1 g CaCl2, 1 mg thiamine per liter.  The fermentor was maintained at 37℃, 350 rpm with air gas flushing and the feeding and outlet pumps were maintained at flow rate of 0.1 h-1. "	"growth_protocol_ch1.1"
"The medium for continuous culture contained 3 g glucose medium consisted with 0.8 g NH4Cl, 0.5 g NaCl, 7.5 g Na2HPO4•2H2O, 3 g KH2PO4 with separately added trace element of 0.2 g MgSO4•7H2O, 0.1 g CaCl2, 1 mg thiamine per liter and the concentraiton of added succinate gradually was raised from 30 g/L to 160 g/L during 9 months.  The initial pH of the medium was set to be pH 8. The fermentor was maintained at 37℃, 350 rpm with air gas flushing and the feeding and outlet pumps were maintained at flow rate of 0.1 h-1. "	"growth_protocol_ch2.1"
"Escherichia coli str. K-12 substr. W3110"	"organism_ch1.1"
"Escherichia coli str. K-12 substr. W3110"	"organism_ch2.1"
"E. coli W3110 (control)"	"source_name_ch1.1"
"Adapted E. coli (DST160, tolerant to high succinic acid concentration)"	"source_name_ch2.1"
"High succinic acid tolerance E.coli_rep Up"	"title.1"
"."	"treatment_protocol_ch1.1"
"."	"treatment_protocol_ch2.1"
"sample type: control"	"characteristics_ch1.1"
"sample type: test"	"characteristics_ch2.1"
"The medium for continuous culture contained 3 g glucose medium consisted with 0.8 g NH4Cl, 0.5 g NaCl, 7.5 g Na2HPO4•2H2O, 3 g KH2PO4 with separately added trace element of 0.2 g MgSO4•7H2O, 0.1 g CaCl2, 1 mg thiamine per liter.  The fermentor was maintained at 37℃, 350 rpm with air gas flushing and the feeding and outlet pumps were maintained at flow rate of 0.1 h-1. "	"growth_protocol_ch1.1"
"The medium for continuous culture contained 3 g glucose medium consisted with 0.8 g NH4Cl, 0.5 g NaCl, 7.5 g Na2HPO4•2H2O, 3 g KH2PO4 with separately added trace element of 0.2 g MgSO4•7H2O, 0.1 g CaCl2, 1 mg thiamine per liter and the concentraiton of added succinate gradually was raised from 30 g/L to 160 g/L during 9 months.  The initial pH of the medium was set to be pH 8. The fermentor was maintained at 37℃, 350 rpm with air gas flushing and the feeding and outlet pumps were maintained at flow rate of 0.1 h-1. "	"growth_protocol_ch2.1"
"Escherichia coli str. K-12 substr. W3110"	"organism_ch1.1"
"Escherichia coli str. K-12 substr. W3110"	"organism_ch2.1"
"E. coli W3110 (control)"	"source_name_ch1.1"
"Adapted E. coli (DST160, tolerant to high succinic acid concentration)"	"source_name_ch2.1"
"."	"treatment_protocol_ch1.1"
"."	"treatment_protocol_ch2.1"