Assessment of the effect of potential antifibrotic compounds on total and aVb6 integrin-mediated TGF-b <v>activation.</v>
M2 macrophages <v>induce </v><g>EMT</g> through the <g>TGF-b</g>/<g>Smad2</g> signaling pathway
Resveratrol inhibits transforming growth factor-b-induced proliferation and differentiation of ex vivo human lung fibroblasts into myofibroblasts through <g>ERK</g>/<g>Akt</g> <u>inhibition </u>and <g>PTEN</g> restoration
Up-regulation of heparan sulfate 6-O-sulfation in <d>idiopathic pulmonary fibrosis</d>
Immunoglobulin A in serum: an old acquaintance as a new prognostic biomarker in <d>idiopathic pulmonary fibrosis</d>
[Pulmonary fibrosis--a therapeutic dilemma?]
<g>Syndecan-2</g> exerts antifibrotic effects by promoting <g>caveolin-1</g>-mediated transforming growth factor-b receptor I internalization and inhibiting transforming growth factor-b1 signaling
Modulation of specific beta cell gene (re)expression during in vitro expansion of human pancreatic islet cells
<r>Regulation </r>of human lung fibroblast <g>C1q</g>-receptors by <g>transforming growth factor-beta</g> and <g>tumor necrosis factor-alpha</g>
Amplification of <g>TGFb</g>
Comparison between conventional and "clinical" assessment of experimental lung <d>fibrosis</d>
[<d>Idiopathic pulmonary fibrosis</d> and <d>lung cancer</d>]
<g>Periostin</g> promotes <d>fibrosis</d> and predicts progression in patients with <d>idiopathic pulmonary fibrosis</d>
<g>CCN5</g> <v>overexpression </v>inhibits profibrotic phenotypes via the <g>PI3K</g>/Akt signaling pathway in lung fibroblasts isolated from patients with <d>idiopathic pulmonary fibrosis</d> and in an in vivo model of <d>lung fibrosis</d>
Pirfenidone attenuates bleomycin-induced pulmonary fibrosis in mice by <r>regulating </r><g>Nrf2</g>/<g>Bach1</g> equilibrium
<g>Extracellular superoxide dismutase</g> has a highly specific <l>localization </l>in <d>idiopathic pulmonary fibrosis</d>/<d>usual interstitial pneumonia</d>
Signaling pathways in the epithelial origins of <d>pulmonary fibrosis</d>
Overexpression of <d>squamous cell carcinoma</d> antigen in <d>idiopathic pulmonary fibrosis</d>: clinicopathological correlations
High levels of <g>IL-6</g> and <g>IL-8</g> characterize early-on <d>idiopathic pulmonary fibrosis</d> acute exacerbations
An ex vivo model to induce early <d>fibrosis</d>-like changes in human precision-cut lung slices
Regulation of the effects of <g>TGF-beta 1</g> by activation of latent <g>TGF-beta 1</g> and differential <e>expression </e>of <g>TGF-beta receptors (T beta R-I and T beta R-II</g>) in <d>idiopathic pulmonary fibrosis</d>
The role of halofuginone in fibrosis: more to be explored? Fibrosis, which can be defined as an abnormal or excessive accumulation of extracellular matrix (ECM), particularly fibrillar collagens, is a key driver of progressive organ dysfunction in many inflammatory and metabolic diseases, including idiopathic pulmonary fibrosis (IPF), cirrhosis, nephropathy, and oral submucous fibrosis (OSF)
Genomewide RNA expression profiling in lung identifies distinct signatures in <d>idiopathic pulmonary arterial hypertension</d> and <d>secondary pulmonary hypertension</d>
Establishment of the mouse model of acute exacerbation of <d>idiopathic pulmonary fibrosis</d>
Dehydroepiandrosterone has strong antifibrotic effects and is decreased in <d>idiopathic pulmonary fibrosis</d>
Peripheral depletion of NK cells and imbalance of the Treg/Th17 axis in <d>idiopathic pulmonary fibrosis</d> patients
Developmental Reprogramming in Mesenchymal Stromal Cells of Human Subjects with <d>Idiopathic Pulmonary Fibrosis</d>
Metformin <d>attenuates lung fibrosis</d> development via <g>NOX4</g> <u>suppression.</u>
<g>Plasminogen activator inhibitor 1</g>, fibroblast apoptosis resistance, and aging-related susceptibility to lung <d>fibrosis</d>
<u>Inhibition </u>of <g>HSP27</g> blocks <d>fibrosis</d> development and EMT features by promoting <g>Snail</g> degradation
Cytokine gene polymorphisms and serum cytokine levels in patients with <d>idiopathic pulmonary fibrosis</d>
<g>miR-9-5p</g> suppresses pro-fibrogenic transformation of fibroblasts and prevents organ <d>fibrosis</d> by targeting <g>NOX4</g> and <g>TGFBR2</g>
Raised serum levels of <g>IGFBP-1</g> and <g>IGFBP-2</g> in <d>idiopathic pulmonary fibrosis</d>
Determining the True Selectivity Profile of av Integrin Ligands Using Radioligand Binding: Applying an Old Solution to a New Problem
Signalling pathways from NADPH oxidase-4 to <d>idiopathic pulmonary fibrosis</d>
<r>Effects </r>of a leukotriene B4 receptor antagonist on bleomycin-induced <d>pulmonary fibrosis</d>
<g>Pigment epithelium-derived factor</g> in <d>idiopathic pulmonary fibrosis</d>: a role in aberrant angiogenesis
Profibrotic role of <g>WNT10A</g> via <g>TGF-b</g> signaling in <d>idiopathic pulmonary fibrosis</d>
Activated human T lymphocytes inhibit <g>TGFb</g>-induced fibroblast to myofibroblast differentiation via prostaglandins D2 and E2
The Role of PPARs in Lung <d>Fibrosis</d>
Methylation-mediated <g>BMPER</g> <e>expression </e>in fibroblast activation in vitro and lung <d>fibrosis</d> in mice in vivo
<d>Fibrosis</d> of two: Epithelial cell-fibroblast interactions in <d>pulmonary fibrosis</d>
Peptide-mediated inhibition of <g>mitogen-activated protein kinase-activated protein kinase-2</g> ameliorates bleomycin-induced <d>pulmonary fibrosis</d>
Free radical generation induces epithelial-to-mesenchymal transition in lung epithelium via a <g>TGF-b1</g>-dependent mechanism
The potential application of strategic released apigenin from polymeric carrier in pulmonary fibrosis
Role of integrin-<v>mediated </v><g>TGFbeta</g> <v>activation </v>in the pathogenesis of <d>pulmonary fibrosis</d>
Novel pharmacological approaches to manage <d>interstitial lung fibrosis</d> in the twenty-first century
Lipoxin A4 Attenuates Constitutive and <g>TGF-b1</g>-Dependent Profibrotic Activity in Human Lung Myofibroblasts
<v>Overexpression </v>of <g>Sulf2</g> in <d>idiopathic pulmonary fibrosis</d>
Essential role for the <g>ATG4B</g> protease and autophagy in bleomycin-induced <d>pulmonary fibrosis</d>
Microarray profiling reveals <u>suppressed </u>interferon stimulated gene program in fibroblasts from scleroderma-associated <d>interstitial lung disease</d>
<g>Hsp90</g> <r>regulation </r>of fibroblast activation in <d>pulmonary fibrosis</d>
<g>Glucagon like peptide-1</g> attenuates bleomycin-induced <d>pulmonary fibrosis</d>, involving the <u>inactivation </u>of NF-kB in mice
Smooth muscle alpha-actin <e>expression </e>and myofibroblast differentiation by <g>TGFbeta</g> are <v>dependent </v>upon <g>MK2</g>
The K+ channel <g>KCa3.1</g> as a novel target for <d>idiopathic pulmonary fibrosis</d>
<g>MiR-185</g>/<g>AKT</g> and <g>miR-29a</g>/collagen 1a pathways are <v>activated </v>in <d>IPF</d>
Arsenic trioxide inhibits transforming growth factor-b1-induced <d>fibroblast to myofibroblast differentiation</d> in vitro and bleomycin induced lung <d>fibrosis</d> in vivo
<g>Spiruchostatin A</g> inhibits proliferation and differentiation of fibroblasts from patients with <d>pulmonary fibrosis</d>
<v>Elevated </v><g>sL1</g>-CAM levels in BALF and serum of <d>IPF</d> patients
Lung myofibroblasts are characterized by <u>down-regulated </u><g>cyclooxygenase-2</g> and its main metabolite, prostaglandin E2
Cigarette Smoke Enhances the Expression of Profibrotic Molecules in Alveolar Epithelial Cells
<g>Wilms' tumor 1</g> (<g>Wt1</g>) regulates pleural mesothelial cell plasticity and transition into myofibroblasts in <d>idiopathic pulmonary fibrosis</d>
<g>miR-26a</g> suppresses EMT by disrupting the <g>Lin28B</g>/<g>let-7d</g> axis: potential cross-talks among miRNAs in <d>IPF</d>
microRNA-1343 attenuates pathways of <d>fibrosis</d> by targeting the <g>TGF-b</g> receptors
Kinase <u>inhibitors </u>fail to induce mesenchymal-epithelial transition in fibroblasts from fibrotic lung tissue
Microarray identifies ADAM family members as key responders to <g>TGF-beta1</g> in alveolar epithelial cells
<g>Transgelin</g> is a direct target of <g>TGF-beta</g>/<g>Smad3</g>-dependent epithelial cell <d>migration in lung fibrosis</d>
The mannose-6-phosphate analogue, PXS64, inhibits <d>fibrosis</d> via <g>TGF-b1</g> pathway in human lung fibroblasts
<u>Reduced </u><e>expression </e>of <g>BMP3</g> contributes to the development of <d>pulmonary fibrosis</d> and predicts the unfavorable prognosis in IIP patients
Role of <g>CD248</g> as a potential severity marker in <d>idiopathic pulmonary fibrosis</d>
<g>IL-4</g> polymorphisms, HRCT score and lung tissue markers in <d>idiopathic pulmonary fibrosis</d>
Early growth response transcription factors: key mediators of <d>fibrosis</d> and novel targets for anti-fibrotic therapy
<g>Toll-like receptor 4</g> activation attenuates profibrotic response in control lung fibroblasts but not in fibroblasts from patients with <d>IPF</d>
Titration of non-replicating adenovirus as a vector for <v>transducing </v>active <g>TGF-beta1</g> gene <e>expression </e>causing <d>inflammation</d> and fibrogenesis in the lungs of C57BL/6 mice
Herpes <d>virus infection</d> is associated with vascular remodeling and <d>pulmonary hypertension</d> in <d>idiopathic pulmonary fibrosis</d>
Effect of substrate stiffness on pulmonary fibroblast activation by <g>TGF-b</g>
<g>BAX inhibitor-1</g>-associated <g>V-ATPase</g> glycosylation <v>enhances </v>collagen degradation in <d>pulmonary fibrosis</d>
Sphingosine-1-phosphate lyase is an endogenous suppressor of <d>pulmonary fibrosis</d>: role of <g>S1P</g> signalling and autophagy
<g>Matrix metalloproteinase (MMP)-19</g> <u>deficient </u>fibroblasts display a profibrotic phenotype
A translational preclinical model of <d>interstitial pulmonary fibrosis</d> and <d>pulmonary hypertension</d>: mechanistic pathways driving disease pathophysiology
Comparative study of transforming growth factor-b signalling and regulatory molecules in human and canine <d>idiopathic pulmonary fibrosis</d>
A critical role for the <g>mTORC2</g> pathway in <d>lung fibrosis</d>
Cytokine gene polymorphisms and BALF cytokine levels in <d>interstitial lung diseases</d>
<g>PI3K</g> p110y <v>overexpression </v>in <d>idiopathic pulmonary fibrosis lung</d> tissue and fibroblast cells: in vitro effects of its inhibition
Low-dose paclitaxel ameliorates <d>pulmonary fibrosis</d> by suppressing <g>TGF-b1</g>/<g>Smad3</g> pathway via <g>miR-140</g> upregulation
MicroRNAs in <d>idiopathic pulmonary fibrosis</d>
Two-Way Conversion between Lipogenic and Myogenic Fibroblastic Phenotypes Marks the Progression and Resolution of Lung <d>Fibrosis</d>
Membrane type-matrix metalloproteinases in <d>idiopathic pulmonary fibrosis</d>
<g>BARD1</g> mediates <g>TGF-b</g> signaling in <d>pulmonary fibrosis</d>
Increased <d>alveolar</d> soluble <g>annexin V</g> promotes <d>lung inflammation</d> and <d>fibrosis</d>
Autophagy in <d>idiopathic pulmonary fibrosis</d>
Microencapsulation of lefty-secreting engineered cells for <d>pulmonary fibrosis</d> therapy in mice
Bile acids induce activation of alveolar epithelial cells and lung fibroblasts through farnesoid X receptor-dependent and independent pathways
<g>TGF-beta</g> driven lung <d>fibrosis</d> is macrophage dependent and blocked by Serum amyloid P
<g>TGF-b1</g> <v>induces </v><g>Fstl1</g> via the <g>Smad3</g>-<g>c-Jun</g> pathway in lung fibroblasts
Exercise <u>Reduces </u>Lung <d>Fibrosis</d>
Genetic polymorphism in <g>matrix metalloproteinase-9</g> and <g>transforming growth factor-b1</g> and susceptibility to <d>combined pulmonary fibrosis</d> and <d>emphysema</d> in a Chinese population
MS80, a novel sulfated oligosaccharide, inhibits <d>pulmonary fibrosis</d> by targeting <g>TGF-beta1</g> both in vitro and in vivo
Protective role of gambogic acid in experimental <d>pulmonary fibrosis</d> in vitro and in vivo
Sputum biomarkers in <d>IPF</d>: Evidence for raised gene <e>expression </e>and protein level of <g>IGFBP-2</g>, <g>IL-8</g> and <g>MMP-7</g>
Sorafenib ameliorates bleomycin-induced <d>pulmonary fibrosis</d>: potential roles in the inhibition of epithelial-mesenchymal transition and fibroblast activation
<g>Forkhead Box F1</g> (<g>FOXF1</g>) <u>represses </u>cell growth, COL1 and <g>ARPC2</g> <e>expression </e>in lung fibroblasts in vitro
[Different cytokine profiles in <d>usual interstitial pneumonia</d> and <d>nonspecific interstitial pneumonia</d>]
Targeting of <g>Discoidin Domain Receptor 2</g> (<g>DDR2</g>) Prevents Myofibroblast Activation and Neovessel Formation During <d>Pulmonary Fibrosis</d>
<g>MicroRNA-29c</g> regulates apoptosis sensitivity via modulation of the cell-surface death receptor, Fas, in lung fibroblasts
Simvastatin attenuates <g>TGF-b1</g>-induced epithelial-mesenchymal transition in human alveolar epithelial cells
Expression of <g>suppressor of cytokine signaling 1</g> in the peripheral blood of patients with <d>idiopathic pulmonary fibrosis</d>
Profibrotic role of <g>miR-154</g> in <d>pulmonary fibrosis</d>
Role of <g>protease-activated receptor-2</g> in <d>idiopathic pulmonary fibrosis</d>
<e>Expression </e>of mucosa-related integrin alphaEbeta7 on <d>alveolar T</d> cells in <d>interstitial lung diseases</d>
Anchorage-independent colony growth of pulmonary fibroblasts derived from fibrotic human lung tissue
Cytoskeletal protein modulation in <d>pulmonary alveolar myofibroblasts</d> during <d>idiopathic pulmonary fibrosis</d>
<g>Aortic carboxypeptidase-like protein</g> (<g>ACLP</g>) enhances lung myofibroblast differentiation through transforming growth factor b receptor-dependent and -independent pathways
The latent form of <g>TGFbeta(1)</g> is induced by <g>TNFalpha</g> through an <g>ERK</g> specific pathway and is <v>activated </v>by asbestos-derived reactive oxygen species in vitro and in vivo
<g>Transglutaminase 2</g> and its role in <d>pulmonary fibrosis</d>
Differential effects of human neutrophil peptide-1 on growth factor and <g>interleukin-8</g> production by human lung fibroblasts and epithelial cells
Sunitinib, a Small-Molecule Kinase <u>Inhibitor,</u>
Fibroblasts from <d>idiopathic pulmonary fibrosis</d> and normal lungs differ in growth rate, apoptosis, and tissue <u>inhibitor </u>of metalloproteinases <e>expression.</e> <d>Idiopathic pulmonary fibrosis</d> (<d>IPF</d>) is a <d>chronic lung disorder</d> characterized by fibroblast proliferation and extracellular matrix accumulation
Transforming growth factor-b1 downregulates <g>vascular endothelial growth factor</g>-D expression in human lung fibroblasts via the <g>Jun NH2-terminal kinase</g> signaling pathway
<g>Ubiquitin carboxyl-terminal hydrolase-L5</g> promotes <g>TGFb-1</g> signaling by de-ubiquitinating and stabilizing <g>Smad2</g>/<g>Smad3</g> in <d>pulmonary fibrosis</d>
<g>Chop</g>
<g>Focal adhesion kinase</g> signaling determines the fate of lung epithelial cells in response to <g>TGF-b</g>
Effects of particulate matter from straw burning on <d>lung fibrosis</d> in mice
<g>miR -221</g> targets <g>HMGA2</g> to inhibit bleomycin -induced <d>pulmonary fibrosis</d> by regulating <g>TGF -b1</g>/<g>Smad3</g>-induced EMT
<g>VCAM-1</g> is a <g>TGF-b1</g> inducible gene <v>upregulated </v>in <d>idiopathic pulmonary fibrosis</d>
<g>EZH2</g> enhances the differentiation of fibroblasts into myofibroblasts in <d>idiopathic pulmonary fibrosis</d>
Effect of pirfenidone on proliferation, <g>TGF-b</g>-induced myofibroblast differentiation and fibrogenic activity of primary human lung fibroblasts
<g>WISP1</g> mediates <g>IL-6</g>-dependent proliferation in primary human lung fibroblasts
<d>Idiopathic pulmonary fibrosis</d>: immunohistochemical analysis provides fresh insights into lung tissue remodelling with implications for novel prognostic markers
Amplified canonical transforming growth factor-b signalling<i>via</i><d>heat shock</d> protein 90 in <d>pulmonary fibrosis</d>
[Quantifying plasma levels of <g>transforming growth factor beta1</g> in <d>idiopathic pulmonary fibrosis</d>]
The matricellular protein <g>CCN1</g> enhances <g>TGF-b1</g>/<g>SMAD3</g>-dependent profibrotic signaling in fibroblasts and contributes to fibrogenic responses to <d>lung injury</d>
Tubastatin ameliorates <d>pulmonary fibrosis</d> by targeting the TGFb-PI3K-<g>Akt</g> pathway
<v>Upregulation </v>of alveolar <e>levels </e>of activin B, but not activin A, in lungs of west highland white terriers with <d>idiopathic pulmonary fibrosis</d> and <d>diffuse alveolar damage</d>
Absence of <g>Thy-1</g> results in <g>TGF-b</g> induced <g>MMP-9</g> expression and confers a profibrotic phenotype to human lung fibroblasts
Lung fibrotic <g>tenascin-C</g> <v>upregulation </v>is associated with other extracellular matrix proteins and <v>induced </v>by TGFb1
Tannic acid attenuates TGF-b1-induced epithelial-to-mesenchymal transition by effectively intervening TGF-b signaling in lung epithelial cells
Shikonin suppresses pulmonary fibroblasts proliferation and activation by <r>regulating </r><g>Akt</g> and <g>p38</g>
Abrogation of <g>TGF-beta1</g>-induced fibroblast-myofibroblast differentiation by <g>histone deacetylase</g> <u>inhibition.</u> <d>Idiopathic pulmonary fibrosis</d> (<d>IPF</d>) is a devastating disease with no known effective pharmacological therapy
<g>JAK2</g> mediates <d>lung fibrosis</d>, <d>pulmonary vascular remodelling</d> and <d>hypertension</d> in <d>idiopathic pulmonary fibrosis</d>: an experimental study
<g>AKT2</g>
Regulation of myofibroblast differentiation by <g>miR-424</g> during epithelial-to-mesenchymal transition
Bleomycin in the setting of <d>lung fibrosis</d> induction: From biological mechanisms to counteractions
MicroRNA-101 attenuates pulmonary fibrosis by inhibiting fibroblast proliferation and activation
<g>Extracellular Matrix Metalloproteinase Inducer</g> (<g>EMMPRIN</g>) promotes lung fibroblast proliferation, survival and differentiation to myofibroblasts
<g>TRPV4</g> mediates myofibroblast differentiation and <d>pulmonary fibrosis</d> in mice
Modulation of <g>CD11c</g>+ lung dendritic cells in respect to <g>TGF-b</g> in experimental <d>pulmonary fibrosis</d>
Melatonin attenuates <g>TGFb1</g>-induced epithelial-mesenchymal transition in lung alveolar epithelial cells
Long-acting human serum albumin-thioredoxin fusion protein suppresses bleomycin-induced <d>pulmonary fibrosis progression</d>
Induction of epithelial-mesenchymal transition in alveolar epithelial cells by <g>transforming growth factor-beta1</g>: potential role in <d>idiopathic pulmonary fibrosis</d>
<r>Deregulation </r>of selective autophagy during aging and <d>pulmonary fibrosis</d>: the role of <g>TGFb1</g>
<v>Increased </v>interleukin-1 receptor antagonist in <d>idiopathic pulmonary fibrosis</d>
Recent advances in molecular targets and treatment of <d>idiopathic pulmonary fibrosis</d>: focus on <g>TGFbeta</g> signaling and the myofibroblast
<g>TIAM1</g> inhibits lung fibroblast differentiation in <d>pulmonary fibrosis</d>
Re-evaluation of fibrogenic cytokines in <d>lung fibrosis</d>
Targeting genes for treatment in <d>idiopathic pulmonary fibrosis</d>: challenges and opportunities, promises and pitfalls
Defect of pro-<g>hepatocyte growth factor</g> activation by fibroblasts in <d>idiopathic pulmonary fibrosis</d>
Epithelial Cell Mitochondrial Dysfunction and <g>PINK1</g>
<g>Bone morphogenetic protein</g>-inducer tilorone identified by high-throughput screening is antifibrotic in vivo
Pleural mesothelial cell differentiation and invasion in <d>fibrogenic lung injury</d>
<l>Release </l>of biologically active <g>TGF-beta1</g> by alveolar epithelial cells results in <d>pulmonary fibrosis</d>
<g>IL-17A</g> deficiency mitigates bleomycin-induced complement activation during <d>lung fibrosis</d>
IPF lung fibroblasts have a senescent phenotype
<g>RhoA</g> signaling <r>modulates </r><g>cyclin D1</g> <e>expression </e>in human lung fibroblasts; implications for <d>idiopathic pulmonary fibrosis</d>
Studies of <g>hepatocyte growth factor</g> in bronchoalveolar lavage fluid in chronic <d>interstitial lung diseases</d>
Autophagy and <d>inflammation</d> in chronic <d>respiratory disease</d>
Inhibitory effect of <g>receptor for advanced glycation end products</g> (<g>RAGE</g>) on the <g>TGF-b</g>-induced alveolar epithelial to mesenchymal transition
Cytokine gene polymorphisms in <d>idiopathic pulmonary fibrosis</d>
<g>Cub domain containing protein 1</g> (<g>CDCP1</g>) negatively regulates TGFb signaling and myofibroblast differentiation
Regulation of transforming growth factor-b1-driven lung <d>fibrosis</d> by <g>galectin-3</g>
<e>Effects </e>of the <d>tumor</d> suppressor <g>PTEN</g> on the pathogenesis of <d>idiopathic pulmonary fibrosis</d> in Chinese patients
Increased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in chronic fibrosing <d>interstitial pneumonia</d>
Epigenetic <r>Regulation </r>of <g>Caveolin-1</g>
Mechanisms of <d>fibrosis</d> in <d>coal workers' pneumoconiosis</d>
Expression of <g>150-kDa oxygen-regulated protein</g> (<g>ORP150</g>) stimulates bleomycin-induced <d>pulmonary fibrosis and dysfunction</d> in mice
Different effects of growth factors on proliferation and matrix production of normal and fibrotic human lung fibroblasts
Role of endoplasmic reticulum stress in age-related susceptibility to lung <d>fibrosis</d>
Are mast cells instrumental for <d>fibrotic diseases</d>? <d>Idiopathic pulmonary fibrosis</d> (<d>IPF</d>) is a <d>fatal lung disorder</d> of unknown etiology characterized by accumulation of lung fibroblasts and extracellular matrix deposition, ultimately leading to compromised tissue architecture and lung function capacity
Alveolar epithelial cell injury with Epstein-Barr virus <v>upregulates </v><g>TGFbeta1</g> <e>expression.</e> <d>Idiopathic pulmonary fibrosis</d> (<d>IPF</d>) is a refractory and lethal <d>interstitial lung disease</d> characterized by alveolar epithelial cells apoptosis, fibroblast proliferation, and ECM protein deposition
<d>Pulmonary fibrosis</d>: pathogenesis, etiology and regulation
Activated MCTC mast cells infiltrate diseased lung areas in <d>cystic fibrosis</d> and <d>idiopathic pulmonary fibrosis</d>
<g>miR</g>-323a-3p regulates <d>lung fibrosis</d> by targeting multiple profibrotic pathways
<g>PPAR</g>-y ligands repress <g>TGFb</g>-induced myofibroblast differentiation by targeting the <g>PI3K</g>/<g>Akt</g> pathway: implications for therapy of <d>fibrosis</d>
<g>TGF-b1</g> <v>stimulates </v><g>HDAC4</g> nucleus-to-cytoplasm <l>translocation </l>and <g>NADPH oxidase 4</g>-derived reactive oxygen species in normal human lung fibroblasts
Effects of <d>cigarette smoke extract</d> on A549 cells and human lung fibroblasts treated with <g>transforming growth factor-beta1</g> in a coculture system
De-ubiquitinating enzyme, <g>USP11</g>, promotes <g>transforming growth factor b-1</g> signaling through stabilization of transforming growth factor b receptor II
Single-cell RNA sequencing identifies diverse roles of epithelial cells in <d>idiopathic pulmonary fibrosis</d>
The antifibrotic effects and mechanisms of microRNA-26a action in <d>idiopathic pulmonary fibrosis</d>
Phosphatase and tensin homolog deleted on chromosome 10 contributes to phenotype transformation of fibroblasts in <d>idiopathic pulmonary fibrosis</d> via multiple pathways
Lower expression of platelet derived growth factor is associated with better overall survival rate of patients with idiopathic nonspecific interstitial pneumonia
MicroRNA-326 regulates profibrotic functions of transforming growth factor-b in <d>pulmonary fibrosis</d>
<g>Endothelin-1</g> <v>induces </v>alveolar epithelial-mesenchymal transition through endothelin type A receptor-<v>mediated </v><e>production </e>of <g>TGF-beta1</g>
Investigation of bone marrow mesenchymal stem cells (BM MSCs) involvement in <d>Idiopathic Pulmonary Fibrosis</d> (<d>IPF</d>)
<g>Neutrophil elastase</g> promotes myofibroblast <d>differentiation in lung fibrosis</d>
<g>MAP3K19</g>
Differential mRNA expression of <g>insulin-like growth factor-1</g> splice variants in patients with <d>idiopathic pulmonary fibrosis</d> and <d>pulmonary sarcoidosis</d>
<g>p63</g> - Key molecule in the early phase of <d>epithelial abnormality</d> in <d>idiopathic pulmonary fibrosis</d>
Effect of Renshen Pingfei Decoction, a traditional Chinese prescription, on <d>IPF</d> <v>induced </v>by Bleomycin in rats and <r>regulation </r>of <g>TGF-b1</g>/<g>Smad3</g>
Pathogenesis of <d>idiopathic pulmonary fibrosis</d>
Macrophage <g>Bone Morphogenic Protein Receptor 2</g> (<g>BMPR2</g>) <u>depletion </u>in <d>Idiopathic Pulmonary Fibrosis</d> (<d>IPF</d>) and Group III Pulmonary <d>Hypertension</d>
<u>Reduced </u><g>Ets Domain-containing Protein Elk1</g>
Nitric oxide attenuates epithelial-mesenchymal transition in alveolar epithelial cells
<g>HSP27</g> regulates <g>TGF-b</g> mediated lung fibroblast differentiation through the <g>Smad3</g> and <g>ERK</g> pathways
<g>Cartilage oligomeric matrix protein</g> in <d>idiopathic pulmonary fibrosis</d>
Negative regulation of myofibroblast differentiation by <g>PTEN</g> (Phosphatase and Tensin Homolog Deleted on chromosome 10)
Data on <g>CUX1</g> isoforms in <d>idiopathic pulmonary fibrosis lung</d> and <d>systemic sclerosis</d> skin tissue sections
Alveolar epithelial cells express mesenchymal proteins in patients with <d>idiopathic pulmonary fibrosis</d>
<e>Expression </e>of <g>WNT5A</g> in <d>Idiopathic Pulmonary Fibrosis</d> and Its <r>Control </r>by <g>TGF-b</g> and <g>WNT7B</g> in Human Lung Fibroblasts
<d>Idiopathic Pulmonary Fibrosis</d>: Aging, Mitochondrial Dysfunction, and Cellular Bioenergetics
<g>SPARC</g> suppresses apoptosis of <d>idiopathic pulmonary fibrosis</d> fibroblasts through constitutive <v>activation </v>of <g>beta-catenin</g>
Resveratrol-Mediated Repression and Reversion of Prostatic Myofibroblast Phenoconversion
[The potential role of cytokines expression in <d>idiopathic pulmonary fibrosis</d>]
Effect of an immunotoxin to <g>folate receptor beta</g> on bleomycin-induced <d>experimental pulmonary fibrosis</d>
The hedgehog system machinery controls transforming growth factor-b-dependent myofibroblastic differentiation in humans: involvement in <d>idiopathic pulmonary fibrosis</d>
<v>Elevated </v><e>expression </e>of <g>NEU1</g> sialidase in <d>idiopathic pulmonary fibrosis</d> <v>provokes </v>pulmonary collagen deposition, <d>lymphocytosis</d>, and <d>fibrosis</d>
Genetic partitioning of <g>interleukin-6</g> signalling in mice dissociates <g>Stat3</g> from <g>Smad3</g>-mediated <d>lung fibrosis</d>
Reactive oxygen species are required for maintenance and differentiation of primary lung fibroblasts in <d>idiopathic pulmonary fibrosis</d>
<v>Upregulation </v>of <g>activin</g>-B and <g>follistatin</g> in <d>pulmonary fibrosis</d> - a translational study using human biopsies and a specific inhibitor in mouse <d>fibrosis</d> models
Oxidant-antioxidant imbalance as a potential contributor to the progression of human <d>pulmonary fibrosis</d>
Increased production and immunohistochemical localization of <g>transforming growth factor-beta</g> in <d>idiopathic pulmonary fibrosis</d>
<u>Inhibition </u>of the <g>KCa3.1</g>
<g>FGF-1</g> reverts epithelial-mesenchymal transition induced by <g>TGF-{beta}1</g> through MAPK/ERK kinase pathway
Lactic acid is elevated in <d>idiopathic pulmonary fibrosis</d> and induces myofibroblast differentiation via pH-dependent activation of transforming growth factor-b
Preventive and therapeutic effects of thymosin b4 N-terminal fragment Ac-SDKP in the bleomycin model of pulmonary fibrosis
Epithelial cell alpha3beta1 integrin links <g>beta-catenin</g> and Smad signaling to promote myofibroblast formation and <d>pulmonary fibrosis</d>
EMT and <d>interstitial lung disease</d>: a mysterious relationship
Pirfenidone exerts antifibrotic effects through <u>inhibition </u>of GLI transcription factors
<g>STAT3</g>-mediated signaling dysregulates lung fibroblast-myofibroblast activation and differentiation in UIP/IPF
Epithelial stem cell exhaustion in the pathogenesis of <d>idiopathic pulmonary fibrosis</d>
FAK-related nonkinase is a multifunctional negative regulator of <d>pulmonary fibrosis</d>
Nitrated fatty acids reverse <d>pulmonary fibrosis</d> by dedifferentiating myofibroblasts and promoting collagen uptake by alveolar macrophages
Berberine attenuates bleomycin induced <d>pulmonary toxicity</d> and <d>fibrosis</d> via <u>suppressing </u><g>NF-kB</g> dependant <g>TGF-b</g> <v>activation:</v> a biphasic experimental study
<g>N-acetyl-L-cysteine</g> inhibits <g>TGF-beta1</g>-induced profibrotic responses in fibroblasts
Interleukin-17 induces human alveolar epithelial to mesenchymal cell transition via the <g>TGF-b1</g> <v>mediated </v><g>Smad2/3</g> and <g>ERK1/2</g> <v>activation.</v> <d>Idiopathic pulmonary fibrosis</d> (<d>IPF</d>) is a chronic and usually progressive <d>lung disease</d> and the epithelial-mesenchymal transition (EMT) may play an important role in the pathogenesis of <d>pulmonary fibrosis</d>
<g>Transforming growth factor b1</g> (<g>TGFb1</g>)-induced CD44V6-<g>NOX4</g> signaling in pathogenesis of <d>idiopathic pulmonary fibrosis</d>
<g>TGF-beta1</g> induces human alveolar epithelial to mesenchymal cell transition (EMT)
Thalidomide prevents bleomycin-induced <d>pulmonary fibrosis</d> in mice
Identification and validation of differentially expressed transcripts by RNA-sequencing of formalin-fixed, paraffin-embedded (FFPE) lung tissue from patients with Idiopathic Pulmonary Fibrosis
Intratracheal bleomycin causes airway remodeling and airflow obstruction in mice
Significance of <v>elevated </v>procollagen-III-peptide and <g>transforming growth factor-beta</g> levels of bronchoalveolar lavage fluids from <d>idiopathic pulmonary fibrosis</d> patients
<g>MiR-338</g>* targeting <g>smoothened</g> to inhibit <d>pulmonary fibrosis</d> by epithelial-mesenchymal transition
Proteasomal regulation of <d>pulmonary fibrosis</d>
Pleural mesothelial cells in <d>pleural and lung diseases</d>
<d>Idiopathic pulmonary fibrosis</d>: an altered fibroblast proliferation linked to <d>cancer</d> biology
Current and novel drug therapies for <d>idiopathic pulmonary fibrosis</d>
Epithelium-specific deletion of <g>TGF-b</g> receptor type II protects mice from bleomycin-induced <d>pulmonary fibrosis</d>
<g>Caveolin-1</g>: a critical regulator of <d>lung fibrosis</d> in <d>idiopathic pulmonary fibrosis</d>
<g>Renin</g> is an angiotensin-independent profibrotic mediator: role in <d>pulmonary fibrosis</d>
<g>Protease activated receptor-1</g> regulates macrophage-mediated cellular senescence: a risk for <d>idiopathic pulmonary fibrosis</d>
Role for alpha3 integrin in EMT and <d>pulmonary fibrosis</d>
Beyond <g>TGFb</g> - Novel ways to target airway and parenchymal <d>fibrosis</d>
<g>Cthrc1</g> lowers pulmonary collagen associated with bleomycin-induced <d>fibrosis</d> and protects lung function
Wnt coreceptor <g>Lrp5</g> is a driver of <d>idiopathic pulmonary fibrosis</d>
<g>MiR-5100</g> targets <g>TOB2</g> to drive epithelial-mesenchymal transition associated with <v>activating </v><g>smad2/3</g> in lung epithelial cells
The impact of <g>TGF-b</g> on lung <d>fibrosis</d>: from targeting to biomarkers
Mast cell chymase: an indispensable instrument in the pathological symphony of <d>idiopathic pulmonary fibrosis</d>? <d>Idiopathic pulmonary fibrosis</d> (<d>IPF</d>) is a chronic, progressive and fatal <d>lung disease</d> with no known etiology and treatment options
Leucine-rich a-2 glycoprotein promotes <d>lung fibrosis</d> by modulating <g>TGF-b</g> signaling in fibroblasts
<g>NOX4</g>/NADPH oxidase <e>expression </e>is <v>increased </v>in pulmonary fibroblasts from patients with <d>idiopathic pulmonary fibrosis</d> and mediates <g>TGFbeta1</g>-induced fibroblast differentiation into myofibroblasts
Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung fibroblasts
Normal Human Lung Epithelial Cells Inhibit Transforming Growth Factor-b Induced Myofibroblast Differentiation via Prostaglandin E2
Matrix regulation of <d>idiopathic pulmonary fibrosis</d>: the role of enzymes
Carbon monoxide-bound hemoglobin-vesicles for the treatment of bleomycin-induced <d>pulmonary fibrosis</d>
Sustained <g>PI3K</g>
Pirfenidone for the treatment of <d>idiopathic pulmonary fibrosis</d>
miR-18a-5p <u>Inhibits </u>Sub-pleural Pulmonary Fibrosis by Targeting <g>TGF-b</g>
Pirfenidone <u>inhibits </u>the <e>expression </e>of <g>HSP47</g> in <g>TGF-beta1</g>-stimulated human lung fibroblasts
Tissue inhibitor of metalloproteinase-3 is up-regulated by <g>transforming growth factor-beta1</g> in vitro and expressed in fibroblastic foci in vivo in <d>idiopathic pulmonary fibrosis</d>
N-acetylcysteine <u>inhibits </u><g>TNF-alpha</g>, sTNFR, and <g>TGF-beta1</g> release by alveolar macrophages in <d>idiopathic pulmonary fibrosis</d> in vitro
Increased Galectin-9 Concentration and Number of CD4+Foxp3high+Cells in Bronchoalveolar Lavage Fluid of Patients with <d>Cryptogenic Organizing Pneumonia</d>
Rapamycin <v>increases </v><g>CCN2</g> <e>expression </e>of lung fibroblasts via <g>phosphoinositide 3-kinase</g>
[The expressions and meanings of <g>BMP-7</g> and <g>TGF-b</g> in <d>idiopathic pulmonary fibrosis</d> and <d>idiopathic nonspecific interstitial pneumonia</d>]
<g>Yin yang 1</g> is a novel regulator of <d>pulmonary fibrosis</d>
Role of <d>von Hippel-Lindau</d> protein in fibroblast proliferation and <d>fibrosis</d>
<g>X-linked inhibitor of apoptosis</g> regulates lung fibroblast resistance to Fas-mediated apoptosis
<d>Idiopathic pulmonary fibrosis</d>: pathobiology of novel approaches to treatment
Age-driven developmental drift in the pathogenesis of <d>idiopathic pulmonary fibrosis</d>
Endogenous <g>Semaphorin-7A</g>
Progressive transforming growth factor beta1-induced <d>lung fibrosis</d> is blocked by an orally active <g>ALK5</g> kinase <u>inhibitor.</u> <d>Pulmonary fibrosis</d> is characterized by chronic scar formation and deposition of extracellular matrix, resulting in <d>impaired lung function</d> and <d>respiratory failure</d>
Human lung myofibroblast <g>TGFb1</g>-dependent <g>Smad2/3</g> signalling is Ca(2+)-dependent and <r>regulated </r>by <g>KCa3.1</g>
Simvastatin inhibits growth factor expression and modulates profibrogenic markers in lung fibroblasts
The anti-fibrotic effect of <u>inhibition </u>of <g>TGFb</g>-<g>ALK5</g> signalling in experimental <d>pulmonary fibrosis</d> in mice is attenuated in the presence of concurrent y-herpesvirus infection
MicroRNA regulatory networks in <d>idiopathic pulmonary fibrosis</d>
Fibroblastic foci, covered with <d>alveolar epithelia</d> exhibiting <d>epithelial-mesenchymal transition</d>, destroy <d>alveolar septa</d> by disrupting blood flow in <d>idiopathic pulmonary fibrosis</d>
[A role for mesothelial cells in the genesis of <d>idiopathic pulmonary fibrosis</d>?]
<e>Overproduction </e>of collagen and <u>diminished </u><g>SOCS1</g> <e>expression </e>are causally linked in fibroblasts from <d>idiopathic pulmonary fibrosis</d>
Antifibrotic effects of <g>cyclosporine A</g> on <g>TGF-b1</g>-treated lung fibroblasts and lungs from bleomycin-treated mice: role of <g>hypoxia-inducible factor-1a</g>
<g>TGF-beta 1</g> as an enhancer of Fas-mediated apoptosis of lung epithelial cells
<r>Regulation </r>of 26S Proteasome Activity in <d>Pulmonary Fibrosis</d>
Therapeutic targets in fibrotic pathways
Compromised peroxisomes in <d>idiopathic pulmonary fibrosis</d>, a vicious cycle inducing a higher fibrotic response via <g>TGF-b</g> signaling
<d>Lung infection</d> with gamma-herpesvirus induces progressive <d>pulmonary fibrosis</d> in Th2-biased mice
Mode of action of nintedanib in the treatment of <d>idiopathic pulmonary fibrosis</d>
<g>Semaphorin 7a</g>+ regulatory T cells are associated with progressive <d>idiopathic pulmonary fibrosis</d> and are implicated in transforming growth factor-b1-induced <d>pulmonary fibrosis</d>
Mesenchymal Stem Cells Correct Inappropriate Epithelial-mesenchyme Relation in <d>Pulmonary Fibrosis</d>
Increased expression of 5-hydroxytryptamine2A/B receptors in <d>idiopathic pulmonary fibrosis</d>: a rationale for therapeutic intervention
Angiotensin-<g>TGF-beta</g> 1 crosstalk in human <d>idiopathic pulmonary fibrosis</d>: autocrine mechanisms in myofibroblasts and macrophages
<v>Increased </v>deposition of chondroitin/dermatan sulfate glycosaminoglycan and <v>upregulation </v>of b1,3-glucuronosyltransferase I in <d>pulmonary fibrosis</d>
SNAI transcription factors mediate epithelial-mesenchymal transition in <d>lung fibrosis</d>
Proliferation of pulmonary interstitial fibroblasts is mediated by <g>transforming growth factor-beta1</g>-induced release of extracellular <g>fibroblast growth factor-2</g> and <p>phosphorylation </p>of <g>p38</g>
Pathogenesis pathways of <d>idiopathic pulmonary fibrosis</d> in bleomycin-induced <d>lung injury</d> model in mice
Latent cytomegalovirus infection exacerbates experimental <d>pulmonary fibrosis</d> by <v>activating </v><g>TGF-b1</g>
Prognostic factors for <d>idiopathic pulmonary fibrosis</d>: clinical, physiologic, pathologic, and molecular aspects
<r>Effects </r>of antifibrotic agents on <g>TGF-beta1</g>, <g>CTGF</g> and <g>IFN-gamma</g> <e>expression </e>in patients with <d>idiopathic pulmonary fibrosis</d>
Hydrogen peroxide is a diffusible paracrine signal for the induction of epithelial cell death by activated myofibroblasts
<g>Microsomal prostaglandin E synthase-1</g> <u>deficiency </u>exacerbates <d>pulmonary fibrosis</d> induced by bleomycin in mice
<g>Secreted protein acidic and rich in cysteine</g> (<g>SPARC</g>) is upregulated by transforming growth factor (TGF)-b and is required for <g>TGF-b</g>-induced hydrogen peroxide production in fibroblasts
Inhibition of NF-kappaB signaling reduces virus load and gammaherpesvirus-induced <d>pulmonary fibrosis</d>
Effects and mechanisms of pirfenidone, prednisone and acetylcysteine on <d>pulmonary fibrosis</d> in rat <d>idiopathic pulmonary fibrosis</d> models
<g>MiR-338</g>* suppresses fibrotic pathogenesis in <d>pulmonary fibrosis</d> through targeting <g>LPA1</g>
Accelerated epithelial cell senescence in <d>IPF</d> and the inhibitory role of <g>SIRT6</g> in <g>TGF-b</g>-induced senescence of human bronchial epithelial cells
<g>Transforming growth factor-beta1</g> in <d>sarcoidosis</d>
The lncRNA <g>H19</g>
<e>Contribution </e>of the anaphylatoxin receptors, <g>C3aR</g> and <g>C5aR</g>, to the pathogenesis of <d>pulmonary fibrosis</d>
<g>TGF-b1</g> induces <g>tissue factor</g> expression in human lung fibroblasts in a <g>PI3K</g>/<g>JNK</g>/<g>Akt</g>-dependent and <g>AP-1</g>-dependent manner
[Potential role of cytokines in <d>idiopathic pulmonary fibrosis</d>]
Protective role of andrographolide in bleomycin-induced <d>pulmonary fibrosis</d> in mice
Epithelial-mesenchymal transition in chronic <d>hypersensitivity pneumonitis</d>
<g>Serpin B4</g> isoform overexpression is associated with aberrant epithelial proliferation and <d>lung cancer</d> in <d>idiopathic pulmonary fibrosis</d>
Uncoupling of the profibrotic and hemostatic effects of <g>thrombin</g> in <d>lung fibrosis</d>
Interstitial <d>fibrosis</d> and growth factors
Molecular targets in <d>pulmonary fibrosis</d>: the myofibroblast in focus
Immunomodulation by mesenchymal stem cells in treating human <d>autoimmune disease-associated lung fibrosis</d>
<u>Reduced </u>transcription of the <g>Smad4</g> gene during <d>pulmonary carcinogenesis</d> in <d>idiopathic pulmonary fibrosis</d>
Intrinsic defence capacity and therapeutic potential of natriuretic peptides in <d>pulmonary hypertension</d> associated with <d>lung fibrosis</d>
<u>Blockade </u>of the Wnt/b-catenin pathway attenuates bleomycin-induced <d>pulmonary fibrosis</d>
Curcumin inhibits <d>fibrosis</d>-related effects in <d>IPF</d> fibroblasts and in mice following bleomycin-induced <d>lung injury</d>
<g>NADPH oxidase-4</g> mediates myofibroblast activation and fibrogenic responses to <d>lung injury</d>
Anti-fibrotic Role of aB-crystallin Inhibition in Pleural and Subpleural <d>Fibrosis</d>
Pleiotropic effect of the proton pump inhibitor esomeprazole leading to suppression of <d>lung inflammation</d> and <d>fibrosis</d>
Reviews and prospectives of signaling pathway analysis in <d>idiopathic pulmonary fibrosis</d>
Roles of p38 MAPK and <g>JNK</g> in <g>TGF-b1</g>-induced human alveolar epithelial to mesenchymal transition
Control of virus reactivation arrests pulmonary herpesvirus-induced <d>fibrosis</d> in IFN-gamma receptor-<u>deficient </u>mice
BALF N-acetylglucosaminidase and <g>beta-galactosidase</g> activities in <d>idiopathic pulmonary fibrosis</d>
Predisposition for disrepair in the aged lung
Possible involvement of pirfenidone metabolites in the antifibrotic action of a therapy for <d>idiopathic pulmonary fibrosis</d>
Evaluation of permeability alteration and epithelial-mesenchymal transition induced by <g>transforming growth factor-b1</g> in A549, NCI-H441, and Calu-3 cells: Development of an in vitro model of respiratory epithelial cells in <d>idiopathic pulmonary fibrosis</d>
Epithelial contribution to the pro-fibrotic stiff microenvironment and myofibroblast population in lung <d>fibrosis</d>
Interactions between <g>b-catenin</g> and <g>transforming growth factor-b</g> signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (<g>CREB)-binding protein</g> (<g>CBP</g>)
BAL cytokine profile in different <d>interstitial lung diseases</d>: a focus on <d>systemic sclerosis</d>
<g>Syndecan-2</g> is a novel target of <g>insulin-like growth factor binding protein-3</g> and is <v>over-expressed </v>in <d>fibrosis</d>
Diagnostic Values For Club Cell Secretory Protein (<g>CC16</g>) in Serum of Patients of Combined Pulmonary Fibrosis and Emphysema
<e>Effects </e>of <g>thymosin b4</g> and its N-terminal fragment Ac-SDKP on <g>TGF-b</g>-treated human lung fibroblasts and in the mouse model of bleomycin-induced <d>lung fibrosis</d>
Matrix metalloproteinase 3 is a mediator of <d>pulmonary fibrosis</d>
An <u>inhibitor </u>of NADPH oxidase-4 attenuates established <d>pulmonary fibrosis</d> in a <d>rodent disease</d> model
TGF-b1 T869C polymorphism may affect susceptibility to <d>idiopathic pulmonary fibrosis</d> and disease severity
<g>Th1</g>/Th2 cytokine gene polymorphisms in patients with <d>idiopathic pulmonary fibrosis</d>
<u>Inhibition </u>of <g>PI3K</g> prevents the proliferation and differentiation of human lung fibroblasts into myofibroblasts: the role of class I P110 isoforms
<r>Effects </r>of doxycycline on <e>production </e>of growth factors and matrix metalloproteinases in <d>pulmonary fibrosis</d>
Anti-pulmonary fibrotic activity of salvianolic acid B was screened by a novel method based on the cyto-biophysical properties
Cytokines in human <d>lung fibrosis</d>
Human placental mesenchymal stem cells of fetal origins-alleviated <d>inflammation</d> and <d>fibrosis</d> by attenuating <g>MyD88</g> signaling in bleomycin-induced <d>pulmonary fibrosis</d> mice
Roles for <g>insulin-like growth factor I</g> and <g>transforming growth factor-beta</g> in <d>fibrotic lung disease</d>
<e>Expression </e>of <g>RXFP1</g>
Role of <g>caveolin-1</g> in <d>fibrotic diseases</d>
Olodaterol shows anti-fibrotic efficacy in in vitro and in vivo models of <d>pulmonary fibrosis</d>
Novel Mechanisms for the Antifibrotic Action of Nintedanib
Plasma <g>CCN2</g> (connective tissue growth factor; <g>CTGF</g>) is a potential biomarker in <d>idiopathic pulmonary fibrosis</d> (<d>IPF</d>)
Azithromycin attenuates myofibroblast differentiation and lung <d>fibrosis</d> development through <d>proteasomal degradation</d> of <g>NOX4</g>
Transforming Growth Factor (TGF)-b Promotes de Novo Serine Synthesis for Collagen <e>Production.</e> <g>TGF-b</g> <v>promotes </v>excessive collagen deposition in <d>fibrotic diseases</d> such as <d>idiopathic pulmonary fibrosis</d> (<d>IPF</d>)
Association between cytokine removal by polymyxin B hemoperfusion and improved pulmonary oxygenation in patients with acute exacerbation of <d>idiopathic pulmonary fibrosis</d>
Crosstalk between <g>TGF-b1</g> and complement activation augments epithelial <d>injury in pulmonary fibrosis</d>
[The morphology and molecular bases of damage to the stem cell niche of respiratory acini in <d>idiopathic interstitial pneumonias</d>]
Pirfenidone inhibits myofibroblast differentiation and <d>lung fibrosis</d> development during insufficient mitophagy
Bleomycin and <g>IL-1beta</g>-mediated <d>pulmonary fibrosis</d> is <g>IL-17A</g> dependent
Insulin-like growth factor binding proteins 3 and 5 are <v>overexpressed </v>in <d>idiopathic pulmonary fibrosis</d> and contribute to extracellular matrix deposition
<g>VEGF</g> ameliorates pulmonary <d>hypertension</d> through inhibition of endothelial apoptosis in experimental lung <d>fibrosis</d> in rats
Rapamycin regulates connective tissue growth factor expression of lung epithelial cells via phosphoinositide 3-kinase
miR-199a-5p Is <v>upregulated </v>during fibrogenic response to tissue injury and mediates TGFbeta-induced lung fibroblast activation by targeting <g>caveolin-1</g>
Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental <d>pulmonary fibrosis</d>
Integrated analyses identify the involvement of microRNA-26a in epithelial-mesenchymal transition during <d>idiopathic pulmonary fibrosis</d>
Differential <e>expression </e>of alpha E beta 7 integrins on bronchoalveolar lavage T lymphocyte subsets: <r>regulation </r>by alpha 4 beta 1-integrin crosslinking and <g>TGF-beta</g>
<v>Increased </v><g>TGF-beta1</g> in the lungs of asbestos-exposed rats and mice: <u>reduced </u><e>expression </e>in <g>TNF-alpha</g> receptor knockout mice
Fibrotic myofibroblasts manifest genome-wide derangements of translational control
<g>Transforming growth factor beta1</g> induces epithelial-to-mesenchymal transition of A549 cells
<r>Regulation </r>of <g>TGF-b</g> storage and activation in the human <d>idiopathic pulmonary fibrosis lung</d>
The anti-fibrotic effects of microRNA-153 by <r>targeting </r><g>TGFBR-2</g> in <d>pulmonary fibrosis</d>
<d>Microsatellite instability</d> in transforming growth factor-beta 1 type II receptor gene in alveolar lining epithelial cells of <d>idiopathic pulmonary fibrosis</d>
The role of cytokines in human <d>lung fibrosis</d>
The Epstein-Barr virus latent membrane protein 1 and transforming growth factor--b1 synergistically induce epithelial--mesenchymal transition in lung epithelial cells
Significant involvement of <g>CCL2</g> (<g>MCP-1</g>) in inflammatory disorders of the lung
<g>TGF-beta</g>-induced EMT: mechanisms and implications for <d>fibrotic lung disease</d>
Pirfenidone <u>inhibits </u><g>TGF-b1</g>-induced <e>over-expression </e>of collagen type I and <d>heat shock</d> protein 47 in A549 cells
Bleomycin induces molecular changes directly relevant to <d>idiopathic pulmonary fibrosis</d>: a model for "active" disease
<u>Defective </u>histone acetylation is <r>responsible </r>for the <u>diminished </u><e>expression </e>of <g>cyclooxygenase 2</g> in <d>idiopathic pulmonary fibrosis</d>
y-Herpes virus-68, but not Pseudomonas aeruginosa or influenza A (H1N1), exacerbates <d>established murine lung fibrosis</d>
Inhibition and role of <g>let-7d</g> in <d>idiopathic pulmonary fibrosis</d>
Pleural mesothelial cell transformation into myofibroblasts and haptotactic migration in response to <g>TGF-beta1</g> in vitro
Association of HLA and cytokine gene polymorphisms with <d>idiopathic pulmonary fibrosis</d>
<g>Connective tissue growth factor</g> <e>expression </e>and <v>induction </v>by <g>transforming growth factor-beta</g> is <u>abrogated </u>by simvastatin via a Rho signaling mechanism
MOXIBUSTION HAS A POSITIVE EFFECT ON PULMONARY FIBROSIS: AN ALTERNATIVE APPROACH
Signaling pathways and their miRNA regulators involved in the etiopathology of <d>idiopathic pulmonary fibrosis</d> (<d>IPF</d>) and <d>hypersensitivity pneumonitis</d> (<d>HP</d>)
Sustained Activation of <g>Toll-Like Receptor 9</g>
<g>miR-21</g> mediates fibrogenic activation of pulmonary fibroblasts and lung <d>fibrosis</d>
Molecular pathogenesis of <d>interstitial pneumonitis</d> with <g>TNF-alpha</g> transgenic mice
<g>Transcription factor GATA-6</g> is <e>expressed </e>in quiescent myofibroblasts in <d>idiopathic pulmonary fibrosis</d>
Inhibitory effects of amines from Citrus reticulata on bleomycin-induced <d>pulmonary fibrosis</d> in rats
Thalidomide <u>reduces </u><g>IL-18</g>, <g>IL-8</g> and <g>TNF-alpha</g> <l>release </l>from alveolar macrophages in <d>interstitial lung disease</d>
MiR-541-5p <r>regulates </r><d>lung fibrosis</d> by <r>targeting </r>cyclic nucleotide phosphodiesterase 1A
The pathogenesis of <d>idiopathic pulmonary fibrosis</d>
Effect of glycosides based standardized fenugreek seed extract in bleomycin-induced <d>pulmonary fibrosis</d> in rats: Decisive role of <g>Bax</g>, <g>Nrf2</g>, <g>NF-kB</g>, <g>Muc5ac</g>, <g>TNF-a</g> and <g>IL-1b</g>
Participation of miR-200 in <d>pulmonary fibrosis</d>
The Anti-fibrotic Effects and Mechanisms of MicroRNA-486-5p in <d>Pulmonary Fibrosis</d>
<d>Autoimmunity</d> to Vimentin Is Associated with Outcomes of Patients with <d>Idiopathic Pulmonary Fibrosis</d>
<g>TGF-beta 1</g>, but not <g>TGF-beta 2</g> or <g>TGF-beta 3</g>, is differentially present in epithelial cells of advanced <d>pulmonary fibrosis</d>: an immunohistochemical study
Lysyl oxidases <r>regulate </r>fibrillar collagen remodelling in idiopathic pulmonary fibrosis
Discovery and validation of extracellular/circulating microRNAs during <d>idiopathic pulmonary fibrosis disease</d> progression
Recombinant human <g>serum amyloid P</g> in healthy volunteers and patients with <d>pulmonary fibrosis</d>
<g>Gremlin</g>-mediated decrease in bone morphogenetic protein signaling promotes <d>pulmonary fibrosis</d>
<v>Increased </v><e>expression </e>of <g>protease nexin-1</g> in fibroblasts during <d>idiopathic pulmonary fibrosis</d> <r>regulates </r><g>thrombin</g> activity and <g>fibronectin</g> <e>expression.</e> <d>Idiopathic pulmonary fibrosis</d> (<d>IPF</d>) is a chronic <d>diffuse lung disease</d> characterized by an accumulation of excess fibrous material in the lung
The role of microRNA-155/liver X receptor pathway in experimental and <d>idiopathic pulmonary fibrosis</d>
Hyper-responsiveness of <d>IPF</d>/<d>UIP</d> fibroblasts: interplay between <g>TGFbeta1</g>, <g>IL-13</g> and <g>CCL2</g>
<d>Idiopathic pulmonary fibrosis</d> in relation to gene polymorphisms of <g>transforming growth factor-b1</g> and <g>plasminogen activator inhibitor 1</g>
<g>TNF-alpha</g>, PDGF, and <g>TGF-beta(1)</g> <e>expression </e>by primary mouse bronchiolar-alveolar epithelial and mesenchymal cells: <g>tnf-alpha</g> induces <g>TGF-beta(1)</g>
<g>Transforming Growth Factor Beta 1</g>
Epithelial-to-mesenchymal transition and its role in <g>EGFR</g>-mutant <d>lung adenocarcinoma</d> and <d>idiopathic pulmonary fibrosis</d>
<g>Cysteine-rich protein 1</g> is regulated by <g>transforming growth factor-b1</g> and expressed in lung <d>fibrosis</d>